BSEP Antibody / Bile Salt Export Pump / ABCB11

Biorbyt

BSEP Antibody / Bile Salt Export Pump / ABCB11

10

Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Western blot: 1-2ug/ml,Immunohistochemistry (FFPE): 1-2ug/ml for 30 min at RT IHC-P, WB

Research Use Only

Monoclonal

BSEP/7534

Unconjugated

ABCB11

ATP binding cassette subfamily B member 11

ABC16, BRIC2, BSEP, PFIC-2, PFIC2, PGY4, SPGP, bile salt export pump, ABC member 16, MDR/TAP subfamily, ATP-binding cassette sub-family B member 11, ATP-binding cassette, sub-family B (MDR/TAP), member 11, progressive familial intrahepatic cholestasis 2, sister p-glycoprotein

Mouse

IgG

Bile salt export pump

ATP-binding cassette (ABC) transporters are an evolutionarily conserved family of proteins that catalyze the transport of molecules across extra- and intracellular membranes through the energy of ATP hydrolysis. ABC genes comprise seven subfamilies, designated ABC1, Mdr/TAP, MRP, ALD, OABP, GCN20 and White. The secretion of bile salt molecules from blood into bile is a major driving force for bile formation. Bile salt export pump (BSEP) is a member of the Mdr/TAP subfamily of ABC transporters that mediates the transport of bile acids across the hepatocyte canalicular membrane and regulates bile acid-dependent bile secretion. BSEP contains putative phosphorylation sites for protein kinase A, protein kinase C (PKC) and Ca2+-calmodulin dependent kinase II, whose regulation may be dependent on bile salt concentration.

Human

-20°C

12352203