BT2

MedChem Express

BT2 [34576-94-8]

10

34576-94-8

Research Use Only

99.85

C9H4Cl2O2S

247.102

BT2 is a BCKDC kinase (BDK) inhibitor with an IC50 of 3.19 microM. BT2 binding to BDK triggers helix movements in the N-terminal domain, resulting in the dissociation of BDK from the branched-chain alpha-ketoacid dehydrogenase complex (BCKDC)[1]. BT2 (compound 4) is also a potent and selective Mcl-1 inhibitor with a Ki value of 59 microM[2].

O=C(O)C1=C(C2=CC=C(C=C2S1)Cl)Cl

-20°C

12352200