The data was published in the journal Oncotarget in 2017.PMID: 28460437
![Indirect ELISA analysis was performed by coating the plate with recombinant Multiple Tags Positive Control ( 6xHis-MBP-DDDDK-V5-HSV-HA-T7-Myc-S) (GTX130342-pro) (57.14-0.89 nM). Coated protein was probed with c-Myc antibody [9E10] (GTX20032) (1 microg/mL). Goat antibody Mouse IgG antibody (HRP) (1:10000) was used to detect the bound primary antibody.](https://www.genetex.com/upload/website/prouct_img/normal/GTX20032/GTX20032_82200350_20240621_ELISA_Indirect_24062501_888.webp "Indirect ELISA analysis was performed by coating the plate with recombinant Multiple Tags Positive Control ( 6xHis-MBP-DDDDK-V5-HSV-HA-T7-Myc-S) (GTX130342-pro) (57.14-0.89 nM). Coated protein was probed with c-Myc antibody [9E10] (GTX20032) (1 microg/mL). Goat antibody Mouse IgG antibody (HRP) (1:10000) was used to detect the bound primary antibody.")
The data was published in the journal Oncotarget in 2017.PMID: 28460437
c-Myc antibody [9E10]
GTX20032
ApplicationsFlow Cytometry, ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ELISA, ImmunoCytoChemistry
Product group Antibodies
ReactivityHuman
TargetMYC
Overview
- SupplierGeneTex
- Product Namec-Myc antibody [9E10]
- Delivery Days Customer9
- ApplicationsFlow Cytometry, ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ELISA, ImmunoCytoChemistry
- CertificationResearch Use Only
- ClonalityMonoclonal
- ConjugateUnconjugated
- Gene ID4609
- Target nameMYC
- Target descriptionMYC proto-oncogene, bHLH transcription factor
- Target synonymsMRTL, MYCC, bHLHe39, c-Myc, myc proto-oncogene protein, avian myelocytomatosis viral oncogene homolog, class E basic helix-loop-helix protein 39, myc-related translation/localization regulatory factor, proto-oncogene c-Myc, transcription factor p64, v-myc avian myelocytomatosis viral oncogene homolog, v-myc myelocytomatosis viral oncogene homolog
- HostMouse
- IsotypeIgG1
- Protein IDP01106
- Protein NameMyc proto-oncogene protein
- Scientific DescriptionThis gene is a proto-oncogene and encodes a nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. The encoded protein forms a heterodimer with the related transcription factor MAX. This complex binds to the E box DNA consensus sequence and regulates the transcription of specific target genes. Amplification of this gene is frequently observed in numerous human cancers. Translocations involving this gene are associated with Burkitt lymphoma and multiple myeloma in human patients. There is evidence to show that translation initiates both from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site, resulting in the production of two isoforms with distinct N-termini. [provided by RefSeq, Aug 2017]
- ReactivityHuman
- Storage Instruction2°C to 8°C
- UNSPSC12352203
References
- Roy S, Zaker A, Mer A, et al. Large-scale phenogenomic analysis of human cancers uncovers frequent alterations affecting SMC5/6 complex components in breast cancer. NAR Cancer. 2023,5(3):zcad047. doi: 10.1093/narcan/zcad047Read this paper
- Li S, Lyu S, Liu Y, et al. Cauliflower mosaic virus P6 Dysfunctions Histone Deacetylase HD2C to Promote Virus Infection. Cells. 2021,10(9). doi: 10.3390/cells10092278Read this paper
- Chang YC, Peng YX, Yu BH, et al. VCP maintains nuclear size by regulating the DNA damage-associated MDC1-p53-autophagy axis in Drosophila. Nat Commun. 2021,12(1):4258. doi: 10.1038/s41467-021-24556-0Read this paper
- Fu SJ, Hu MC, Peng YJ, et al. CUL4-DDB1-CRBN E3 Ubiquitin Ligase Regulates Proteostasis of ClC-2 Chloride Channels: Implication for Aldosteronism and Leukodystrophy. Cells. 2020,9(6). doi: 10.3390/cells9061332Read this paper
- Chiu SY, Chung HJ, Chen YT, et al. A nonsense mutant of the hepatitis B virus large S protein antagonizes multiple tumor suppressor pathways through c-Jun activation domain-binding protein1. PLoS One. 2019,14(3):e0208665. doi: 10.1371/journal.pone.0208665Read this paper
- Anand R, Jasrotia A, Bundschuh D, et al. NBS1 promotes the endonuclease activity of the MRE11-RAD50 complex by sensing CtIP phosphorylation. EMBO J. 2019,38(7). doi: 10.15252/embj.2018101005Read this paper
- Emperador-Melero J, Huson V, van Weering J, et al. Vti1a/b regulate synaptic vesicle and dense core vesicle secretion via protein sorting at the Golgi. Nat Commun. 2018,9(1):3421. doi: 10.1038/s41467-018-05699-zRead this paper
- Thattikota Y, Tollis S, Palou R, et al. Cdc48/VCP Promotes Chromosome Morphogenesis by Releasing Condensin from Self-Entrapment in Chromatin. Mol Cell. 2018,69(4):664-676.e5. doi: 10.1016/j.molcel.2018.01.030Read this paper
- Li C, Zeng M, Chi H, et al. Trichosanthin increases Granzyme B penetration into tumor cells by upregulation of CI-MPR on the cell surface. Oncotarget. 2017,8(16):26460-26470. doi: 10.18632/oncotarget.15518Read this paper
- Shen YR, Wang HY, Kuo YC, et al. SEPT12 phosphorylation results in loss of the septin ring/sperm annulus, defective sperm motility and poor male fertility. PLoS Genet. 2017,13(3):e1006631. doi: 10.1371/journal.pgen.1006631Read this paper
Datasheet
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