Untreated (-) and treated (+) HepG2 whole cell extracts (30 microg) were separated by 10% SDS-PAGE, and the membrane was blotted with c-Myc (phospho Thr58/Ser62) antibody [SZ02-06] (GTX01137) diluted at 1:500. The HRP-conjugated anti-rabbit IgG antibody (GTX213110-01) was used to detect the primary antibody.
c-Myc (phospho Thr58/Ser62) antibody [SZ02-06] - Recombinant antibody, Orthogonal Validated
GTX01137
Overview
- SupplierGeneTex
- Product Namec-Myc (phospho Thr58/Ser62) antibody [SZ02-06] - Recombinant antibody, Orthogonal Validated
- Delivery Days Customer9
- ApplicationsWestern Blot
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone IDSZ02-06
- Concentration1 mg/ml
- ConjugateUnconjugated
- Gene ID4609
- Target nameMYC
- Target descriptionMYC proto-oncogene, bHLH transcription factor
- Target synonymsavian myelocytomatosis viral oncogene homolog; bHLHe39; class E basic helix-loop-helix protein 39; c-Myc; MRTL; myc proto-oncogene protein; MYCC; myc-related translation/localization regulatory factor; proto-oncogene c-Myc; transcription factor p64; v-myc avian myelocytomatosis viral oncogene homolog; v-myc myelocytomatosis viral oncogene homolog
- HostRabbit
- IsotypeIgG
- Modification TypePhosphorylated
- Scientific DescriptionThis gene is a proto-oncogene and encodes a nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. The encoded protein forms a heterodimer with the related transcription factor MAX. This complex binds to the E box DNA consensus sequence and regulates the transcription of specific target genes. Amplification of this gene is frequently observed in numerous human cancers. Translocations involving this gene are associated with Burkitt lymphoma and multiple myeloma in human patients. There is evidence to show that translation initiates both from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site, resulting in the production of two isoforms with distinct N-termini. [provided by RefSeq, Aug 2017]
- ReactivityHuman
- Storage Instruction2°C to 8°C,-20°C or -80°C
- UNSPSC12352203