Camptothecin

MedChem Express

Camptothecin [7689-03-4]

10

7689-03-4

Research Use Only

99.86

C20H16N2O4

348.358

Camptothecin (CPT), a kind of alkaloid, is a DNA topoisomerase I (Topo I) inhibitor with an IC 50 of 679 nM [1] . Camptothecin (CPT) exhibits powerful antineoplastic activity against colorectal, breast, lung and ovarian cancers, modulates hypoxia-inducible factor-1alpha (HIF-1alpha) activity by changing microRNAs (miRNA) expression patterns in human cancer cells [2] [3] .

O=C1C2=C([C@@](O)(CC)C(OC2)=O)C=C(N1C3)C(C3=C4)=NC5=C4C=CC=C5

2°C to 8°C

12352200