Western blot analysis of extracts of Jurkat cells using Caspase-3 Polyclonal Antibody at dilution of 1:1000.
Western blot analysis of extracts of Jurkat cells using Caspase-3 Polyclonal Antibody at dilution of 1:1000.
CASP3 Polyclonal Antibody
E-AB-60646
Product group Antibodies
Overview
- SupplierElabscience
- Product NameCASP3 Polyclonal Antibody
- Delivery Days Customer12
- CertificationResearch Use Only
- Scientific DescriptionThis gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimers disease. Alternative splicing of this gene results in two transcript variants that encode the same protein.
- UNSPSC12352203