CDK2 antibody [N1C3]
GTX101226
ApplicationsWestern Blot
Product group Antibodies
ReactivityFish, Human
TargetCDK2
Overview
- SupplierGeneTex
- Product NameCDK2 antibody [N1C3]
- Delivery Days Customer9
- Application Supplier NoteWB: 1:500-1:10000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- ApplicationsWestern Blot
- CertificationResearch Use Only
- ClonalityPolyclonal
- Concentration1 mg/ml
- ConjugateUnconjugated
- Gene ID1017
- Target nameCDK2
- Target descriptioncyclin dependent kinase 2
- Target synonymsCDKN2, p33(CDK2), cyclin-dependent kinase 2, cdc2-related protein kinase, cell division protein kinase 2, p33 protein kinase
- HostRabbit
- IsotypeIgG
- Protein IDP24941
- Protein NameCyclin-dependent kinase 2
- Scientific DescriptionThe protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein kinase is highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2. It is a catalytic subunit of the cyclin-dependent protein kinase complex, whose activity is restricted to the G1-S phase, and essential for cell cycle G1/S phase transition. This protein associates with and regulated by the regulatory subunits of the complex including cyclin A or E, CDK inhibitor p21Cip1 (CDKN1A) and p27Kip1 (CDKN1B). Its activity is also regulated by its protein phosphorylation. Two alternatively spliced variants and multiple transcription initiation sites of this gene have been reported. [provided by RefSeq]
- ReactivityFish, Human
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203
References
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- Liang ML, Chen CH, Liu YR, et al. Abemaciclib, A Selective CDK4/6 Inhibitor, Restricts the Growth of Pediatric Ependymomas. Cancers (Basel). 2020,12(12). doi: 10.3390/cancers12123597Read this paper
- Li JM, Tseng CW, Lin CC, et al. Upregulation of LGALS1 is associated with oral cancer metastasis. Ther Adv Med Oncol. 2018,10:1758835918794622. doi: 10.1177/1758835918794622Read this paper
- Liu YH, Weng YP, Tsai HY, et al. Aqueous extracts of Paeonia suffruticosa modulates mitochondrial proteostasis by reactive oxygen species-induced endoplasmic reticulum stress in pancreatic cancer cells. Phytomedicine. 2018,46:184-192. doi: 10.1016/j.phymed.2018.03.037Read this paper
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- Yuan SY, Shiau MY, Ou YC, et al. Miconazole induces apoptosis via the death receptor 5-dependent and mitochondrial-mediated pathways in human bladder cancer cells. Oncol Rep. 2017,37(6):3606-3616. doi: 10.3892/or.2017.5608Read this paper
- Liu YH, Weng YP, Lin HY, et al. Aqueous extract of Polygonum bistorta modulates proteostasis by ROS-induced ER stress in human hepatoma cells. Sci Rep. 2017,7:41437. doi: 10.1038/srep41437Read this paper
- Kuo CY, Li X, Stark JM, et al. RNF4 regulates DNA double-strand break repair in a cell cycle-dependent manner. Cell Cycle. 2016,15(6):787-98. doi: 10.1080/15384101.2016.1138184Read this paper
- Huang AM, Kao YT, Toh S, et al. UBE2M-mediated p27(Kip1) degradation in gemcitabine cytotoxicity. Biochem Pharmacol. 2011,82(1):35-42. doi: 10.1016/j.bcp.2011.03.026Read this paper


![ELISA analysis of antigen using GTX60572 CDK2 antibody [1A6]. Black : Control antigen 100ng Purple : Antigen 10ng Blue : Antigen 50ng Red : Antigen 100ng](https://www.genetex.com/upload/website/prouct_img/normal/GTX60572/GTX60572_20170912_ELISA_w_23061123_771.webp)