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CFI-400437

Research Use Only
SYN-1207
SYNkinase
Estimated Purity>95%
Product group Chemicals
Molecular Weight492.6 . 72.9
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Overview

  • Supplier
    SYNkinase
  • Product Name
    CFI-400437 [1168722-82-4]
  • Delivery Days Customer
    10
  • Certification
    Research Use Only
  • Estimated Purity
    >95%
  • Molecular Formula
    C29H28N6O2 . 2HCl
  • Molecular Weight
    492.6 . 72.9
  • Scientific Description
    CFI-400437 is a potent PLK4 inhibitor (IC50=0.6nM) and selective against other members of the PLK family (>10microM). Against a broad panel of kinases, only a small subset is significantly inhibited. CFI-400437 is a potent inhibitor of MCF-7, MDA-MB-468 and MDA-MB-231 cell growth and very effective in a mouse xenograft model of tumor growth. - Chemical. CAS: 1168722-82-4. Formula: C29H28N6O2 . 2HCl. MW: 492.6 . 72.9. CFI-400437 is a potent PLK4 inhibitor (IC50=0.6nM) and selective against other members of the PLK family (>10microM). Against a broad panel of kinases, only a small subset is significantly inhibited. CFI-400437 is a potent inhibitor of MCF-7, MDA-MB-468 and MDA-MB-231 cell growth and very effective in a mouse xenograft model of tumor growth.
  • Storage Instruction
    2°C to 8°C
  • UNSPSC
    12352200