CFI-400437

SYNkinase

CFI-400437 [1168722-82-4]

10

1168722-82-4

Research Use Only

>95%

C29H28N6O2 . 2HCl

492.6 . 72.9

CFI-400437 is a potent PLK4 inhibitor (IC50=0.6nM) and selective against other members of the PLK family (>10microM). Against a broad panel of kinases, only a small subset is significantly inhibited. CFI-400437 is a potent inhibitor of MCF-7, MDA-MB-468 and MDA-MB-231 cell growth and very effective in a mouse xenograft model of tumor growth. - Chemical. CAS: 1168722-82-4. Formula: C29H28N6O2 . 2HCl. MW: 492.6 . 72.9. CFI-400437 is a potent PLK4 inhibitor (IC50=0.6nM) and selective against other members of the PLK family (>10microM). Against a broad panel of kinases, only a small subset is significantly inhibited. CFI-400437 is a potent inhibitor of MCF-7, MDA-MB-468 and MDA-MB-231 cell growth and very effective in a mouse xenograft model of tumor growth.

2°C to 8°C

51202000