IHC-Fr analysis of normal human skin (left) and skin tissue in absence of collagenXVII (middle) from patients with inherited skin-blistering disorders using GTX54647 COL17A1 antibody [NC16a-3]. Another skin tissue in absence of laminin 5 (right) was stained with a rabbit anti-laminin 5 antibody.
![WB analysis of keratinocyte extract (E) and keratinocyte medium (M) using GTX54647 COL17A1 antibody [NC16a-3]. This antibody detects collagen XVII and its 120kDa shed ectodomain.](https://www.genetex.com/upload/website/prouct_img/normal/GTX54647/GTX54647_20171211_WB_w_23060900_987.webp "WB analysis of keratinocyte extract (E) and keratinocyte medium (M) using GTX54647 COL17A1 antibody [NC16a-3]. This antibody detects collagen XVII and its 120kDa shed ectodomain.")
IHC-Fr analysis of normal human skin (left) and skin tissue in absence of collagenXVII (middle) from patients with inherited skin-blistering disorders using GTX54647 COL17A1 antibody [NC16a-3]. Another skin tissue in absence of laminin 5 (right) was stained with a rabbit anti-laminin 5 antibody.
COL17A1 antibody [NC16a-3]
GTX54647
ApplicationsWestern Blot, ELISA, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman
TargetCOL17A1
Overview
- SupplierGeneTex
- Product NameCOL17A1 antibody [NC16a-3]
- Delivery Days Customer9
- Antibody SpecificityThis antibody recognizes the NC16a-domain of collagen XVII (aa 545-557). It does not cross-react with mouse and rat skin based on internal testing; other species not tested.
- Application Supplier NoteWB: 1:1000. IHC-P: 1:40. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- ApplicationsWestern Blot, ELISA, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone IDNC16a-3
- ConjugateUnconjugated
- Gene ID1308
- Target nameCOL17A1
- Target descriptioncollagen type XVII alpha 1 chain
- Target synonyms180 kDa bullous pemphigoid antigen 2; alpha 1 type XVII collagen; BA16H23.2; bA16H23.2 (collagen, type XVII, alpha 1 (BP180)); BP180; BPA-2; BPAG2; bullous pemphigoid antigen 2 (180kD); collagen alpha-1(XVII) chain; collagen XVII, alpha-1 polypeptide; collagen, type XVII, alpha 1; ERED; LAD-1; type XVII collagen alpha-1
- HostMouse
- IsotypeIgG1
- Protein IDQ9UMD9
- Protein NameCollagen alpha-1(XVII) chain
- Scientific DescriptionThis gene encodes the alpha chain of type XVII collagen. Unlike most collagens, collagen XVII is a transmembrane protein. Collagen XVII is a structural component of hemidesmosomes, multiprotein complexes at the dermal-epidermal basement membrane zone that mediate adhesion of keratinocytes to the underlying membrane. Mutations in this gene are associated with both generalized atrophic benign and junctional epidermolysis bullosa. Two homotrimeric forms of type XVII collagen exist. The full length form is the transmembrane protein. A soluble form, referred to as either ectodomain or LAD-1, is generated by proteolytic processing of the full length form. [provided by RefSeq, Jul 2008]
- ReactivityHuman
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203