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ProductsBack/Collagen IV antibody [COL-94]
IHC-P analysis of human placenta sections using GTX26311 Collagen IV[COL-94] antibody at 1:500.
IHC-P analysis of human placenta sections using GTX26311 Collagen IV[COL-94] antibody at 1:500.
IHC-P analysis of human placenta sections using GTX26311 Collagen IV[COL-94] antibody at 1:500.

Collagen IV antibody [COL-94]

GTX26311
GeneTex
ApplicationsDot Blot, Electron Microscopy, ImmunoFluorescence, Western Blot, ELISA, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman
TargetCOL4A1
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Overview

  • Supplier
    GeneTex
  • Product Name
    Collagen IV antibody [COL-94]
  • Delivery Days Customer
    9
  • Application Supplier Note
    IHC-P: 1:500. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    Dot Blot, Electron Microscopy, ImmunoFluorescence, Western Blot, ELISA, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    COL-94
  • Conjugate
    Unconjugated
  • Gene ID1282
  • Target name
    COL4A1
  • Target description
    collagen type IV alpha 1 chain
  • Target synonyms
    BSVD, BSVD1, COL4A1s, PADMAL, RATOR, collagen alpha-1(IV) chain, COL4A1 NC1 domain, arresten, collagen IV, alpha-1 polypeptide, collagen of basement membrane, alpha-1 chain
  • Host
    Mouse
  • Isotype
    IgG1
  • Protein IDP02462
  • Protein Name
    Collagen alpha-1(IV) chain
  • Scientific Description
    Collagen IV is a major constituent of the basement membranes along with laminins and enactins. It is composed of alpha 1 IV chain and alpha 2 IV chain in 2:1 ratio . It can form insoluble fibers with high tensile strength. Antibody to collagen IV is useful in detecting the loss of parts of basement membrane in carcinomas.
  • Reactivity
    Human
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • Baker JHE, Kyle AH, Reinsberg SA, et al. Heterogeneous distribution of trastuzumab in HER2-positive xenografts and metastases: role of the tumor microenvironment. Clin Exp Metastasis. 2018,35(7):691-705. doi: 10.1007/s10585-018-9929-3
    Read this paper
  • Huang YH, Yang YL, Huang FC, et al. MicroRNA-29a mitigation of endoplasmic reticulum and autophagy aberrance counteracts in obstructive jaundice-induced fibrosis in mice. Exp Biol Med (Maywood). 2018,243(1):13-21. doi: 10.1177/1535370217741500
    Read this paper
  • Schendel SA. Autologous Adipose-Derived Tissue Matrix Part I: Biologic Characteristics. Aesthet Surg J. 2017,37(9):1062-1068. doi: 10.1093/asj/sjx059
    Read this paper
  • McLane JS, Ligon LA. Stiffened Extracellular Matrix and Signaling from Stromal Fibroblasts via Osteoprotegerin Regulate Tumor Cell Invasion in a 3-D Tumor in Situ Model. Cancer Microenviron. 2016,9(2-3):127-139. doi: 10.1007/s12307-016-0188-z
    Read this paper

Datasheet

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GeneTex anti collagen IV antibody (GTX26586, 1:400, 45 min RT) showed strong staining in FFPE sections of human kidney (Left) with strong red staining observed in glomeruli and liver (Right) with strong staining in sinusoids. Staining for both tissues was consistent with a basement membrane distribution. Slides were steamed in 0.01 M sodium citrate buffer, pH 6.0 at 99-100oC - 20 minutes for antigen retrieval.
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