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ProductsBack/CXCR7 antibody [C1C2], Internal
Boiled and unboiled Raji whole cell and membrane extracts (30 μg) were separated by 10% SDS-PAGE, and the membrane was blotted with CXCR7 antibody [C1C2], Internal (GTX100027) diluted at 1:5000. The HRP-conjugated anti-rabbit IgG antibody (GTX213110-01) was used to detect the primary antibody, and the signal was developed with Trident ECL plus-Enhanced. (WCE: whole cell extract; ME: membrane extract)
Boiled and unboiled Raji whole cell and membrane extracts (30 μg) were separated by 10% SDS-PAGE, and the membrane was blotted with CXCR7 antibody [C1C2], Internal (GTX100027) diluted at 1:5000. The HRP-conjugated anti-rabbit IgG antibody (GTX213110-01) was used to detect the primary antibody, and the signal was developed with Trident ECL plus-Enhanced. (WCE: whole cell extract; ME: membrane extract)
Boiled and unboiled Raji whole cell and membrane extracts (30 μg) were separated by 10% SDS-PAGE, and the membrane was blotted with CXCR7 antibody [C1C2], Internal (GTX100027) diluted at 1:5000. The HRP-conjugated anti-rabbit IgG antibody (GTX213110-01) was used to detect the primary antibody, and the signal was developed with Trident ECL plus-Enhanced. (WCE: whole cell extract; ME: membrane extract)

CXCR7 antibody [C1C2], Internal

GTX100027
GeneTex
ApplicationsFlow Cytometry, ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ELISA, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman, Mouse, Rat
TargetACKR3
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Overview

  • Supplier
    GeneTex
  • Product Name
    CXCR7 antibody [C1C2], Internal
  • Delivery Days Customer
    9
  • Application Supplier Note
    WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    Flow Cytometry, ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ELISA, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    0.14 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID57007
  • Target name
    ACKR3
  • Target description
    atypical chemokine receptor 3
  • Target synonyms
    CMKOR1, CXC-R7, CXCR-7, CXCR7, GPR159, RDC-1, RDC1, atypical chemokine receptor 3, C-X-C chemokine receptor type 7, G protein-coupled receptor, G-protein coupled receptor 159, G-protein coupled receptor RDC1 homolog, chemokine (C-X-C motif) receptor 7, chemokine orphan receptor 1
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDP25106
  • Protein Name
    Atypical chemokine receptor 3
  • Scientific Description
    This gene encodes a member of the G-protein coupled receptor family. Although this protein was earlier thought to be a receptor for vasoactive intestinal peptide (VIP), it is now considered to be an orphan receptor, in that its endogenous ligand has not been identified. The protein is also a coreceptor for human immunodeficiency viruses (HIV). Translocations involving this gene and HMGA2 on chromosome 12 have been observed in lipomas. [provided by RefSeq]
  • Reactivity
    Human, Mouse, Rat
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • Wei Y, Zheng X, Huang T, et al. Human embryonic stem cells secrete macrophage migration inhibitory factor: A novel finding. PLoS One. 2023,18(8):e0288281. doi: 10.1371/journal.pone.0288281
    Read this paper
  • Song S, Liu B, Habibie H, et al. D-dopachrome tautomerase contributes to lung epithelial repair via atypical chemokine receptor 3-dependent Akt signaling. EBioMedicine. 2021,68:103412. doi: 10.1016/j.ebiom.2021.103412
    Read this paper
  • Cheng CW, Liao WL, Chen PM, et al. MiR-139 Modulates Cancer Stem Cell Function of Human Breast Cancer through Targeting CXCR4. Cancers (Basel). 2021,13(11). doi: 10.3390/cancers13112582
    Read this paper
  • Wei ST, Huang YC, Hsieh ML, et al. Atypical chemokine receptor ACKR3/CXCR7 controls postnatal vasculogenesis and arterial specification by mesenchymal stem cells via Notch signaling. Cell Death Dis. 2020,11(5):307. doi: 10.1038/s41419-020-2512-2
    Read this paper
  • Xu T, Yu X, Deng J, et al. CXCR7 regulates epileptic seizures by controlling the synaptic activity of hippocampal granule cells. Cell Death Dis. 2019,10(11):825. doi: 10.1038/s41419-019-2052-9
    Read this paper
  • Becker JH, Gao Y, Soucheray M, et al. CXCR7 Reactivates ERK Signaling to Promote Resistance to EGFR Kinase Inhibitors in NSCLC. Cancer Res. 2019,79(17):4439-4452. doi: 10.1158/0008-5472.CAN-19-0024
    Read this paper
  • Li S, Fong KW, Gritsina G, et al. Activation of MAPK Signaling by CXCR7 Leads to Enzalutamide Resistance in Prostate Cancer. Cancer Res. 2019,79(10):2580-2592. doi: 10.1158/0008-5472.CAN-18-2812
    Read this paper
  • Liu B, Song S, Setroikromo R, et al. CX Chemokine Receptor 7 Contributes to Survival of KRAS-Mutant Non-Small Cell Lung Cancer upon Loss of Epidermal Growth Factor Receptor. Cancers (Basel). 2019,11(4). doi: 10.3390/cancers11040455
    Read this paper
  • Xu S, Tang J, Wang C, et al. CXCR7 promotes melanoma tumorigenesis via Src kinase signaling. Cell Death Dis. 2019,10(3):191. doi: 10.1038/s41419-019-1442-3
    Read this paper
  • Luo Y, Azad AK, Karanika S, et al. Enzalutamide and CXCR7 inhibitor combination treatment suppresses cell growth and angiogenic signaling in castration-resistant prostate cancer models. Int J Cancer. 2018,142(10):2163-2174. doi: 10.1002/ijc.31237
    Read this paper

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