Cyclin E antibody [168]

GeneTex

Cyclin E antibody [168]

9

IP: Use at an assay dependent dilution. WB: Use at an assay dependent dilution. Detects a band of approximately 50 kDa. Optimal dilutions/concentrations should be determined by the end user.

ImmunoPrecipitation, Western Blot

Research Use Only

Monoclonal

168

1 mg/ml

Unconjugated

CCNE1

cyclin E1

CCNE; G1/S-specific cyclin-E1; pCCNE1

Mouse

IgG2a

Cyclin E is a regulatory subunit of Cdk2 and controls G1 / S transition during the mammalian cell cycle. Multiple isoforms of Cyclin E are expressed only in tumors but not in the normal tissues, suggesting a post transcriptional regulation of Cyclin E. In vitro analyses indicated that these truncated variant isoforms of Cyclin E are able to phosphorylate histone H1. Alterations in Cyclin E protein have been implicated as indicators of worse prognosis in various cancers.

-20°C or -80°C,2°C to 8°C

12352203