Cycloastragenol [84605-18-5]

Chemodex

Cycloastragenol [84605-18-5]

10

84605-18-5

Research Use Only

>98%

C30H50O5

490.73

Chemical. CAS: 84605-18-5. Formula: C30H50O5. MW: 490.73. Cycloastragenol is an aglycone of astragaloside IV isolated from Astragalus species. Extensive pharmacological effects have been attributed to cycloastragenol, including telomerase activation, telomere elongation, anti-inflammatory and anti-oxidative properties, improvement of lipid metabolism and wound repair promotion. It has been shown to inhibit endoplasmic reticulum stress-associated TXNIP/NLRP3 inflammasome activation and NLRP3 inflammasome-mediated pyroptosis. It improved immune function in CD8+ T lymphocytes from HIV-1-infected patients. It might be a novel candidate for age-associated diseases. - Cycloastragenol is an aglycone of astragaloside IV isolated from Astragalus species. Extensive pharmacological effects have been attributed to cycloastragenol, including telomerase activation, telomere elongation, anti-inflammatory and anti-oxidative properties, improvement of lipid metabolism and wound repair promotion. It has been shown to inhibit endoplasmic reticulum stress-associated TXNIP/NLRP3 inflammasome activation and NLRP3 inflammasome-mediated pyroptosis. It improved immune function in CD8+ T lymphocytes from HIV-1-infected patients. It might be a novel candidate for age-associated diseases.

O[C@H]1C[C@@]2(C)[C@]3([H])C[C@H](O)[C@@]4([H])C(C)(C)[C@@H](O)CC[C@]45[C@]3(C5)CC[C@]2(C)[C@H]1[C@]6(C)O[C@H](C(C)(O)C)CC6

-20°C

12352200