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ICC/IF analysis of formalin-fixed Jurkat cells using GTX56293 CYP11A1 antibody. Red : Primary antibody Blue : DAPI Permeabilization : 0.1% Triton X-100 in TBS for 5-10 minutes
ICC/IF analysis of formalin-fixed Jurkat cells using GTX56293 CYP11A1 antibody. Red : Primary antibody Blue : DAPI Permeabilization : 0.1% Triton X-100 in TBS for 5-10 minutes
ICC/IF analysis of formalin-fixed Jurkat cells using GTX56293 CYP11A1 antibody. Red : Primary antibody Blue : DAPI Permeabilization : 0.1% Triton X-100 in TBS for 5-10 minutes

CYP11A1 antibody

GTX56293
GeneTex
ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry
DownloadDatasheet
Product group Antibodies
ReactivityHuman, Mouse, Rat
TargetCYP11A1
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Overview

  • Supplier
    GeneTex
  • Product Name
    CYP11A1 antibody
  • Delivery Days Customer
    9
  • Application Supplier Note
    WB: 1:500 - 1:1000. ICC/IF: 1:100 - 1:500. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    ImmunoFluorescence, Western Blot, ImmunoCytoChemistry
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Conjugate
    Unconjugated
  • Gene ID1583
  • Target name
    CYP11A1
  • Target description
    cytochrome P450 family 11 subfamily A member 1
  • Target synonyms
    cholesterol 20-22 desmolase; cholesterol monooxygenase (side-chain cleaving); cholesterol side-chain cleavage enzyme, mitochondrial; CYP11A; CYPXIA1; cytochrome P450 11A1; cytochrome P450 family 11 subfamily A polypeptide 1; cytochrome P450(scc); cytochrome P450, subfamily XIA (cholesterol side chain cleavage); P450SCC; steroid 20-22-lyase
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDP05108
  • Protein Name
    Cholesterol side-chain cleavage enzyme, mitochondrial
  • Scientific Description
    This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the mitochondrial inner membrane and catalyzes the conversion of cholesterol to pregnenolone, the first and rate-limiting step in the synthesis of the steroid hormones. Two transcript variants encoding different isoforms have been found for this gene. The cellular location of the smaller isoform is unclear since it lacks the mitochondrial-targeting transit peptide. [provided by RefSeq, Jul 2008]
  • Reactivity
    Human, Mouse, Rat
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • Association Between 17beta-Estradiol Receptors and Nitric Oxide Signaling Augments High-Altitude Adaptation of Ladakhi Highlanders. Pooja et al., 2021 Jun, High Alt Med Biol
    Read more
  • Transplantation of encapsulated human Leydig-like cells: A novel option for the treatment of testosterone deficiency. Feng X et al., 2021 Jan 1, Mol Cell Endocrinol
    Read more
  • Estrogen receptor (ESR1 and ESR2)-mediated activation of eNOS-NO-cGMP pathway facilitates high altitude acclimatization. Pooja et al., 2020 Sep 1, Nitric Oxide
    Read more
  • FOXO4-DRI alleviates age-related testosterone secretion insufficiency by targeting senescent Leydig cells in aged mice. Zhang C et al., 2020 Jan 20, Aging (Albany NY)
    Read more
  • Alteration in iron efflux affects male sex hormone testosterone biosynthesis in a diet-induced obese rat model. Kurniawan AL et al., 2019 Jul 17, Food Funct
    Read more
  • Establishing a nonlethal and efficient mouse model of male gonadotoxicity by intraperitoneal busulfan injection. Xie Y et al., 2019 Jun 7, Asian J Androl
    Read more