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ProductsBack/Cytokeratin 20 antibody [Ks20.8]

Cytokeratin 20 antibody [Ks20.8]

Research Use Only
GTX72046
GeneTex
ApplicationsImmunoFluorescence, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
DownloadDatasheet
Product group Antibodies
ReactivityHuman, Mouse
TargetKRT20
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Overview

  • Supplier
    GeneTex
  • Product Name
    Cytokeratin 20 antibody [Ks20.8]
  • Delivery Days Customer
    9
  • Antibody Specificity
    This antibody reacts with the 46 kD cytokeratin polypeptide 20, a type I cytokeratin that is found in duodenal epithelium, glandular gastric and pyloric epithelium, urothelium and Merkel cells of the epidermis. It does not cross-react with other cytokerat
  • Application Supplier Note
    Used to identify and differentiate different carcinomas. This antibody can be used on formalin-fixed, paraffin-embedded tissue sections. Prolonged fixation in buffered formalin can destroy the epitope. For optimal results, tissue sections should either be treated with high-temperature based antigenic unmasking technique, or with proteolytic enzymes such as AutoZyme or Pronase. The optimal conditions should be determined by the individual laboratory. This antibody is not suitable for use on cryostat sections or cell smears due to non-specific cross-reaction with negative epithelia. Dilute according to the particular application being used. In general, the 0.05M Borate pH 8.0 containing 0.15M Sodium Chloride, 0.05% Sodium Azide, is a good diluent to use with most antibodies.
  • Applications
    ImmunoFluorescence, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    Ks20.8
  • Conjugate
    Unconjugated
  • Formulation
    Liquid
  • Gene ID54474
  • Target name
    KRT20
  • Target description
    keratin 20
  • Target synonyms
    CD20; CK20; CK-20; cytokeratin 20; K20; keratin 20, type I; keratin, type I cytoskeletal 20; KRT21; protein IT
  • Host
    Mouse
  • Isotype
    IgG2a
  • Protein IDP35900
  • Protein Name
    Keratin, type I cytoskeletal 20
  • Scientific Description
    The protein encoded by this gene is a member of the keratin family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. The type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. This cytokeratin is a major cellular protein of mature enterocytes and goblet cells and is specifically expressed in the gastric and intestinal mucosa. The type I cytokeratin genes are clustered in a region of chromosome 17q12-q21. [provided by RefSeq, Jul 2008]
  • Reactivity
    Human, Mouse
  • Storage Instruction
    2°C to 8°C
  • UNSPSC
    12352203

References

  • Pulmonary tumors associated with the JC virus T-antigen in a transgenic mouse model. Noguchi A et al., 2013 Dec, Oncol Rep
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  • Survival of cancer stem cells under hypoxia and serum depletion via decrease in PP2A activity and activation of p38-MAPKAPK2-Hsp27. Lin SP et al., 2012, PLoS One
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  • Silibinin suppresses the maintenance of colorectal cancer stem-like cells by inhibiting PP2A/AKT/mTOR pathways. Wang JY et al., 2012 May, J Cell Biochem
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