Cytokeratin 4 antibody [6B10]

GeneTex

Cytokeratin 4 antibody [6B10]

9

The antibody reacts with non-cornifying squamous epithelium (e.g., exocervix, esophagus and cornea). Ciliated pseudostratified epithelium of bronchi is weakly stained. Ducts of sweat glands and prostate are focally stained. The antibody may react with som

IHC-P: 1:300. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

Dot Blot, ImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin

Research Use Only

Monoclonal

6B10

Unconjugated

KRT4

keratin 4

CK4; CK-4; CYK4; cytokeratin 4; K4; keratin 4, type II; keratin, type II cytoskeletal 4; type-II keratin Kb4; WSN1

Mouse

IgG1

Intermediate filaments are abundant cytoplasmic structural proteins in most vertebrate cells. Cytokeratins, a group comprised of at least 29 different proteins are characteristic of epithelial and trichocytic cells. Cytokeratin 4 is a member of the type II, neutralto- basic subfamily. It is a 59 kD polypeptide differentially expressed in various human tissues. Cytokeratin 4 can be detected by biochemical or immunohistochemical means in adult non-cornified squamous epithelium such as that of the superficial and intermediate cells of the esophagus, exocervix, tongue, vagina, larynx,pharynx, epiglottis, and anus as well as in the superficial cells of the cornea. In addition, its presence was demonstrated in suprabasal cells of the urinary bladder transitional epithelium, in single cells and cell groups of sweat glands and prostatic ducts and in cylindrical ciliated bronchial cells. Cytokeratin 4 may be detected in squamous cell carcinomas derived from several non-cornified stratified epithelia. Monoclonal anti-cytokeratins are specific markers of epithelial cell differentiation and have been widely used as tools in tumor identification and classification. Monoclonal anti-Cytokeratin 4 is a chain specific antibody which may facilitate typing of normal, metaplastic and neoplastic cells.

Canine, Feline, Guinea Pig, Goat, Hamster, Human, Porcine, Rabbit, Sheep

-20°C or -80°C,2°C to 8°C

12352203