DDX58 antibody

GeneTex

DDX58 antibody

9

WB: 0.5 - 2 microg/mL. IHC-P: 5 microg/mL. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

ImmunoFluorescence, Western Blot, ELISA, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Research Use Only

Polyclonal

1 mg/ml

Unconjugated

RIGI

RNA sensor RIG-I

DDX58, RIG-I, RIG1, RLR-1, SGMRT2, antiviral innate immune response receptor RIG-I, ATP-dependent RNA helicase DDX58, DEAD (Asp-Glu-Ala-Asp) box polypeptide 58, DEAD box protein 58, DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide, DExD/H-box helicase 58, RNA helicase RIG-I, probable ATP-dependent RNA helicase DDX58, retinoic acid-inducible gene 1 protein, retinoic acid-inducible gene I protein

Rabbit

IgG

Antiviral innate immune response receptor RIG-I

The innate immune system detects viral infection by recognizing various viral components and triggers antiviral responses. Like the toll-like receptor 3 (TLR3), the cytoplasmic helicase retinoic acid inducible gene protein 1 (RIG-1) recognizes double-stranded (ds) RNA, a molecular pattern associated with viral infection. Unlike TLR3 however, RIG-1 activates the kinases TBK1 and IKKepsilon through the adaptor protein IPS-1. These kinases then phosphorylate the transcription factors IRF-3 and IRF-7 which are essential for the expression of type-I interferons. RIG-1 is required for the production of interferons in response to RNA viruses including paramyxoviruses, influenza virus, and Japanese encephalitis virus.

-20°C or -80°C,2°C to 8°C

12352203