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ProductsBack/DNA ligase III antibody [1F3]

DNA ligase III antibody [1F3]

GTX70143
GeneTex
ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, Neutralisation/Blocking, Other Application
DownloadDatasheet
Product group Antibodies
ReactivityChicken, Human, Mouse
TargetLIG3
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Overview

  • Supplier
    GeneTex
  • Product Name
    DNA ligase III antibody [1F3] - Orthogonal Validated
  • Delivery Days Customer
    9
  • Application Supplier Note
    WB: 1:500-1:3000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, Neutralisation/Blocking, Other Application
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    1F3
  • Concentration
    1 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID3980
  • Target name
    LIG3
  • Target description
    DNA ligase 3
  • Target synonyms
    DNA ligase 3; LIG2; LIG3alpha; ligase II, DNA, ATP-dependent; ligase III, DNA, ATP-dependent; polydeoxyribonucleotide synthase [ATP] 3
  • Host
    Mouse
  • Isotype
    IgG1
  • Protein IDP49916
  • Protein Name
    DNA ligase 3
  • Scientific Description
    This gene is a member of the DNA ligase family. Each member of this family encodes a protein that catalyzes the joining of DNA ends but they each have a distinct role in DNA metabolism. The protein encoded by this gene is involved in excision repair and is located in both the mitochondria and nucleus, with translation initiation from the upstream start codon allowing for transport to the mitochondria and translation initiation from a downstream start codon allowing for transport to the nucleus. Additionally, alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
  • Reactivity
    Chicken, Human, Mouse
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • TDP1 suppresses chromosomal translocations and cell death induced by abortive TOP1 activity during gene transcription.
    Read more
  • DePARylation is critical for S phase progression and cell survival.
    Read more
  • Replication gaps are a key determinant of PARP inhibitor synthetic lethality with BRCA deficiency.
    Read more
  • WRN regulates pathway choice between classical and alternative non-homologous end joining. Shamanna RA et al., 2016 Dec 6, Nat Commun
    Read more
  • Inhibition of hydrogen sulfide biosynthesis sensitizes lung adenocarcinoma to chemotherapeutic drugs by inhibiting mitochondrial DNA repair and suppressing cellular bioenergetics. Szczesny B et al., 2016 Nov 3, Sci Rep
    Read more
  • Base excision repair defects invoke hypersensitivity to PARP inhibition. Horton JK et al., 2014 Aug, Mol Cancer Res
    Read more
  • Effects of chromatin decondensation on alternative NHEJ. Moscariello M et al., 2013 Nov, DNA Repair (Amst)
    Read more
  • Preventing oxidation of cellular XRCC1 affects PARP-mediated DNA damage responses. Horton JK et al., 2013 Sep, DNA Repair (Amst)
    Read more
  • Interaction between DNA Polymerase beta and BRCA1. Masaoka A et al., 2013, PLoS One
    Read more
  • DNA ligases I and III cooperate in alternative non-homologous end-joining in vertebrates. Paul K et al., 2013, PLoS One
    Read more