ProductsBack/DNA ligase III antibody [1F3]

DNA ligase III antibody [1F3]

Name: DNA ligase III antibody [1F3]
SKU: GTX70143_G10
Availability: BackOrder

GTX70143

ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, Neutralisation/Blocking, Other Application

Product group Antibodies

TargetLIG3

Overview

Supplier
GeneTex
Product Name
DNA ligase III antibody [1F3] - Orthogonal Validated
Delivery Days Customer
9
Application Supplier Note
WB: 1:500-1:3000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Applications
ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, Neutralisation/Blocking, Other Application
Certification
Research Use Only
Clonality
Monoclonal
Clone ID
1F3
Concentration
1 mg/ml
Conjugate
Unconjugated
Gene ID3980
Target name
LIG3
Target description
DNA ligase 3
Target synonyms
DNA ligase 3; LIG2; LIG3alpha; ligase II, DNA, ATP-dependent; ligase III, DNA, ATP-dependent; polydeoxyribonucleotide synthase [ATP] 3
Host
Mouse
Isotype
IgG1
Protein IDP49916
Protein Name
DNA ligase 3
Scientific Description
This gene is a member of the DNA ligase family. Each member of this family encodes a protein that catalyzes the joining of DNA ends but they each have a distinct role in DNA metabolism. The protein encoded by this gene is involved in excision repair and is located in both the mitochondria and nucleus, with translation initiation from the upstream start codon allowing for transport to the mitochondria and translation initiation from a downstream start codon allowing for transport to the nucleus. Additionally, alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Storage Instruction
-20°C or -80°C,2°C to 8°C
UNSPSC
12352203

TDP1 suppresses chromosomal translocations and cell death induced by abortive TOP1 activity during gene transcription.
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DePARylation is critical for S phase progression and cell survival.
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Replication gaps are a key determinant of PARP inhibitor synthetic lethality with BRCA deficiency.
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WRN regulates pathway choice between classical and alternative non-homologous end joining. Shamanna RA et al., 2016 Dec 6, Nat Commun
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Inhibition of hydrogen sulfide biosynthesis sensitizes lung adenocarcinoma to chemotherapeutic drugs by inhibiting mitochondrial DNA repair and suppressing cellular bioenergetics. Szczesny B et al., 2016 Nov 3, Sci Rep
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Base excision repair defects invoke hypersensitivity to PARP inhibition. Horton JK et al., 2014 Aug, Mol Cancer Res
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Effects of chromatin decondensation on alternative NHEJ. Moscariello M et al., 2013 Nov, DNA Repair (Amst)
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Preventing oxidation of cellular XRCC1 affects PARP-mediated DNA damage responses. Horton JK et al., 2013 Sep, DNA Repair (Amst)
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Interaction between DNA Polymerase beta and BRCA1. Masaoka A et al., 2013, PLoS One
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DNA ligases I and III cooperate in alternative non-homologous end-joining in vertebrates. Paul K et al., 2013, PLoS One
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