ProductsBack/DNA ligase III antibody [C2C3], C-term

DNA ligase III antibody [C2C3], C-term

Name: DNA ligase III antibody [C2C3], C-term
SKU: GTX103197_G10
Availability: BackOrder

GTX103197

ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry

Product group Antibodies

TargetLIG3

Overview

Supplier
GeneTex
Product Name
DNA ligase III antibody [C2C3], C-term
Delivery Days Customer
9
Application Supplier Note
WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Applications
ImmunoFluorescence, Western Blot, ImmunoCytoChemistry
Certification
Research Use Only
Clonality
Polyclonal
Concentration
0.15 mg/ml
Conjugate
Unconjugated
Gene ID3980
Target name
LIG3
Target description
DNA ligase 3
Target synonyms
LIG2, LIG3alpha, MTDPS20, DNA ligase 3, ligase II, DNA, ATP-dependent, ligase III, DNA, ATP-dependent, polydeoxyribonucleotide synthase [ATP] 3
Host
Rabbit
Isotype
IgG
Protein IDP49916
Protein Name
DNA ligase 3
Scientific Description
This gene is a member of the DNA ligase family. Each member of this family encodes a protein that catalyzes the joining of DNA ends but they each have a distinct role in DNA metabolism. The protein encoded by this gene is involved in excision repair and is located in both the mitochondria and nucleus, with translation initiation from the upstream start codon allowing for transport to the mitochondria and translation initiation from a downstream start codon allowing for transport to the nucleus. Additionally, alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq]
Storage Instruction
-20°C or -80°C,2°C to 8°C
UNSPSC
12352203

Campalans A, Moritz E, Kortulewski T, et al. Interaction with OGG1 is required for efficient recruitment of XRCC1 to base excision repair and maintenance of genetic stability after exposure to oxidative stress. Mol Cell Biol. 2015,35(9):1648-58. doi: 10.1128/MCB.00134-15
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Abdou I, Poirier GG, Hendzel MJ, et al. DNA ligase III acts as a DNA strand break sensor in the cellular orchestration of DNA strand break repair. Nucleic Acids Res. 2015,43(2):875-92. doi: 10.1093/nar/gku1307
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Kim S, Jo S, Lee H, et al. Lobarstin enhances chemosensitivity in human glioblastoma T98G cells. Anticancer Res. 2013,33(12):5445-51.
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Truong LN, Li Y, Shi LZ, et al. Microhomology-mediated End Joining and Homologous Recombination share the initial end resection step to repair DNA double-strand breaks in mammalian cells. Proc Natl Acad Sci U S A. 2013,110(19):7720-5. doi: 10.1073/pnas.1213431110
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