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ProductsBack/DNA ligase IV antibody [N2C2], Internal

DNA ligase IV antibody [N2C2], Internal

Research Use Only
GTX100100
GeneTex
ApplicationsWestern Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
DownloadDatasheet
Product group Antibodies
ReactivityHuman, Mouse
TargetLIG4
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Overview

  • Supplier
    GeneTex
  • Product Name
    DNA ligase IV antibody [N2C2], Internal
  • Delivery Days Customer
    9
  • Applications
    Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    0.65 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID3981
  • Target name
    LIG4
  • Target description
    DNA ligase 4
  • Target synonyms
    DNA joinase; DNA ligase 4; DNA ligase IV; DNA repair enzyme; LIG4S; ligase IV, DNA, ATP-dependent; polydeoxyribonucleotide synthase [ATP] 4; polynucleotide ligase; sealase
  • Host
    Rabbit
  • Isotype
    IgG
  • Scientific Description
    The protein encoded by this gene is a DNA ligase that joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction. This protein is essential for V(D)J recombination and DNA double-strand break (DSB) repair through nonhomologous end joining (NHEJ). This protein forms a complex with the X-ray repair cross complementing protein 4 (XRCC4), and further interacts with the DNA-dependent protein kinase (DNA-PK). Both XRCC4 and DNA-PK are known to be required for NHEJ. The crystal structure of the complex formed by this protein and XRCC4 has been resolved. Defects in this gene are the cause of LIG4 syndrome. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq]
  • Reactivity
    Human, Mouse
  • Storage Instruction
    2°C to 8°C,-20°C or -80°C
  • UNSPSC
    12352203

References

  • ATM antagonizes NHEJ proteins assembly and DNA-ends synapsis at single-ended DNA double strand breaks. Britton S et al., 2020 Sep 25, Nucleic Acids Res
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  • Protein phosphatase 1 and phosphatase 1 nuclear targeting subunit-dependent regulation of DNA-dependent protein kinase and non-homologous end joining. Zhu S et al., 2017 Oct 13, Nucleic Acids Res
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  • Selective Y centromere inactivation triggers chromosome shattering in micronuclei and repair by non-homologous end joining. Ly P et al., 2017 Jan, Nat Cell Biol
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  • Non-homologous end joining pathway is the major route of protection against 4beta-hydroxywithanolide E-induced DNA damage in MCF-7 cells. You BJ et al., 2014 Mar, Food Chem Toxicol
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