DNA polymerase iota antibody
GTX112137
ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry
Product group Antibodies
TargetPOLI
Overview
- SupplierGeneTex
- Product NameDNA polymerase iota antibody
- Delivery Days Customer9
- Application Supplier NoteWB: 1:500-1:3000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry
- CertificationResearch Use Only
- ClonalityPolyclonal
- Concentration1 mg/ml
- ConjugateUnconjugated
- Gene ID11201
- Target namePOLI
- Target descriptionDNA polymerase iota
- Target synonymsDNA polymerase iota; eta2; polymerase (DNA directed) iota; polymerase (DNA) iota; polymerase (DNA-directed), iota; RAD30 homolog B; RAD30B; RAD3OB
- HostRabbit
- IsotypeIgG
- Protein IDQ9UNA4
- Protein NameDNA polymerase iota
- Scientific DescriptionError-prone DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Favors Hoogsteen base-pairing in the active site. Inserts the correct base with high-fidelity opposite an adenosine template. Exhibits low fidelity and efficiency opposite a thymidine template, where it will preferentially insert guanosine. May play a role in hypermutation of immunogobulin genes. Forms a Schiff base with 5-deoxyribose phosphate at abasic sites, but may not have lyase activity.
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203
References
- Age and insulin-like growth factor-1 impact PCNA monoubiquitination in UVB-irradiated human skin. Hutcherson RJ et al., 2021 Jan-Jun, J Biol ChemRead more
- Replication of an Autonomous Human Parvovirus in Non-dividing Human Airway Epithelium Is Facilitated through the DNA Damage and Repair Pathways. Deng X et al., 2016 Jan, PLoS PathogRead more
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