DNMT1 antibody [N1], N-term
GTX116011
ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ChIP Chromatin ImmunoPrecipitation, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman, Mouse
TargetDNMT1
Overview
- SupplierGeneTex
- Product NameDNMT1 antibody [N1], N-term
- Delivery Days Customer9
- Application Supplier NoteWB: 1:1000-1:10000. ICC/IF: 1:100-1:2000. IHC-P: 1:100-1:1000. IP: 1:100-1:500. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ChIP Chromatin ImmunoPrecipitation, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
- CertificationResearch Use Only
- ClonalityPolyclonal
- Concentration0.18 mg/ml
- ConjugateUnconjugated
- Gene ID1786
- Target nameDNMT1
- Target descriptionDNA methyltransferase 1
- Target synonymsADCADN, AIM, CXXC9, DNMT, HSN1E, MCMT, m.HsaI, DNA (cytosine-5)-methyltransferase 1, CXXC-type zinc finger protein 9, DNA (cytosine-5-)-methyltransferase 1, DNA MTase HsaI, DNA methyltransferase HsaI
- HostRabbit
- IsotypeIgG
- Protein IDP26358
- Protein NameDNA (cytosine-5)-methyltransferase 1
- Scientific DescriptionDNA (cytosine-5-)-methyltransferase 1 has a role in the establishment and regulation of tissue-specific patterns of methylated cytosine residues. Aberrant methylation patterns are associated with certain human tumors and developmental abnormalities. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
- ReactivityHuman, Mouse
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203
References
- Zhao Z, Li J, Feng Y, et al. Host DNA Demethylation Induced by DNMT1 Inhibition Up-Regulates Antiviral OASL Protein during Influenza a Virus Infection. Viruses. 2023,15(8). doi: 10.3390/v15081646Read this paper
- Tu H, Zhang Z, Li J, et al. Loss of MEG3 contributes to the enhanced migration and invasion in arsenic-induced carcinogenesis through NQO1/FSCN1 pathway. Am J Cancer Res. 2023,13(6):2307-2322.Read this paper
- Wu YH, Huang YF, Wu PY, et al. The downregulation of miR-509-3p expression by collagen type XI alpha 1-regulated hypermethylation facilitates cancer progression and chemoresistance via the DNA methyltransferase 1/Small ubiquitin-like modifier-3 axis in ovarian cancer cells. J Ovarian Res. 2023,16(1):124. doi: 10.1186/s13048-023-01191-5Read this paper
- Zhang N, Gao X, Yuan Q, et al. E3 ubiquitin ligase RNF180 prevents excessive PCDH10 methylation to suppress the proliferation and metastasis of gastric cancer cells by promoting ubiquitination of DNMT1. Clin Epigenetics. 2023,15(1):77. doi: 10.1186/s13148-023-01492-yRead this paper
- Wu YH, Huang YF, Wu PY, et al. The Downregulation of miR-509-3p Expression by Collagen Type XI Alpha 1-Regulated Hypermethylation Facilitates Cancer Progression and Chemoresistance via the DNA Methyltransferase 1/Small Ubiquitin-like Modifier-3 Axis in Ovarian Cancer Cells. Res Sq. 2023,:pii: rs.3.rs-2592453. doi: 10.21203/rs.3.rs-2592453/v1.Read this paper
- Wang Q, Li G, Ma X, et al. LncRNA TINCR impairs the efficacy of immunotherapy against breast cancer by recruiting DNMT1 and downregulating MiR-199a-5p via the STAT1-TINCR-USP20-PD-L1 axis. Cell Death Dis. 2023,14(2):76. doi: 10.1038/s41419-023-05609-2Read this paper
- Kawai T, Richards JS, Shimada M. Large-scale DNA demethylation occurs in proliferating ovarian granulosa cells during mouse follicular development. Commun Biol. 2021,4(1):1334. doi: 10.1038/s42003-021-02849-wRead this paper
- Tessier SN, Ingelson-Filpula WA, Storey KB. Epigenetic regulation by DNA methyltransferases during torpor in the thirteen-lined ground squirrel Ictidomys tridecemlineatus. Mol Cell Biochem. 2021,476(11):3975-3985. doi: 10.1007/s11010-021-04214-1Read this paper
- Wang Q, Liu J, You Z, et al. LncRNA TINCR favors tumorigenesis via STAT3-TINCR-EGFR-feedback loop by recruiting DNMT1 and acting as a competing endogenous RNA in human breast cancer. Cell Death Dis. 2021,12(1):83. doi: 10.1038/s41419-020-03188-0Read this paper
- Zhang D, An X, Li Q, et al. Thioguanine Induces Apoptosis in Triple-Negative Breast Cancer by Regulating PI3K-AKT Pathway. Front Oncol. 2020,10:524922. doi: 10.3389/fonc.2020.524922Read this paper
Datasheet
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