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DNMT3B antibody

GTX129127
GeneTex
ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
DownloadDatasheet
Product group Antibodies
TargetDNMT3B
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Overview

  • Supplier
    GeneTex
  • Product Name
    DNMT3B antibody
  • Delivery Days Customer
    9
  • Application Supplier Note
    WB: 1:1000-1:10000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. IP: 1:100-1:500. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    1.29 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID1789
  • Target name
    DNMT3B
  • Target description
    DNA methyltransferase 3 beta
  • Target synonyms
    DNA (cytosine-5-)-methyltransferase 3 beta; DNA (cytosine-5)-methyltransferase 3B; DNA cytosine-5--methyltransferase 3 beta; DNA methyltransferase HsaIIIB; DNA MTase HsaIIIB; FSHD4; ICF; ICF1; M.HsaIIIB
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDQ9UBC3
  • Protein Name
    DNA (cytosine-5)-methyltransferase 3B
  • Scientific Description
    CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase which is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes primarily to the nucleus and its expression is developmentally regulated. Mutations in this gene cause the immunodeficiency-centromeric instability-facial anomalies (ICF) syndrome. Six alternatively spliced transcript variants have been described. The full length sequences of variants 4 and 5 have not been determined. [provided by RefSeq]
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • Loss of MEG3 contributes to the enhanced migration and invasion in arsenic-induced carcinogenesis through NQO1/FSCN1 pathway.
    Read more
  • The downregulation of miR-509-3p expression by collagen type XI alpha 1-regulated hypermethylation facilitates cancer progression and chemoresistance via the DNA methyltransferase 1/Small ubiquitin-like modifier-3 axis in ovarian cancer cells.
    Read more
  • The Downregulation of miR-509-3p Expression by Collagen Type XI Alpha 1-Regulated Hypermethylation Facilitates Cancer Progression and Chemoresistance via the DNA Methyltransferase 1/Small Ubiquitin-like Modifier-3 Axis in Ovarian Cancer Cells.
    Read more
  • DNMT3A/miR-129-2-5p/Rac1 Is an Effector Pathway for SNHG1 to Drive Stem-Cell-like and Invasive Behaviors of Advanced Bladder Cancer Cells.
    Read more
  • DNMT3A and DNMT3B Targeting as an Effective Radiosensitizing Strategy in Embryonal Rhabdomyosarcoma. Camero S et al., 2021 Oct 30, Cells
    Read more
  • Epigenetic underpinnings of freeze avoidance in the goldenrod gall moth, Epiblema scudderiana. Williamson SM et al., 2021 Oct, J Insect Physiol
    Read more
  • Epigenetic regulation by DNA methyltransferases during torpor in the thirteen-lined ground squirrel Ictidomys tridecemlineatus. Tessier SN et al., 2021 Nov, Mol Cell Biochem
    Read more
  • miR-190 promotes malignant transformation and progression of human urothelial cells through CDKN1B/p27 inhibition. Huang S et al., 2021 Apr 29, Cancer Cell Int
    Read more
  • USP7 negatively controls global DNA methylation by attenuating ubiquitinated histone-dependent DNMT1 recruitment. Li J et al., 2020, Cell Discov
    Read more
  • Insulin and Metformin Control Cell Proliferation by Regulating TDG-Mediated DNA Demethylation in Liver and Breast Cancer Cells. Yan JB et al., 2020 Sep 25, Mol Ther Oncolytics
    Read more

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