DNMT3B antibody
GTX129127
ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
TargetDNMT3B
Overview
- SupplierGeneTex
- Product NameDNMT3B antibody
- Delivery Days Customer9
- Application Supplier NoteWB: 1:1000-1:10000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. IP: 1:100-1:500. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
- CertificationResearch Use Only
- ClonalityPolyclonal
- Concentration1.29 mg/ml
- ConjugateUnconjugated
- Gene ID1789
- Target nameDNMT3B
- Target descriptionDNA methyltransferase 3 beta
- Target synonymsFSHD4, ICF, ICF1, M.HsaIIIB, DNA (cytosine-5)-methyltransferase 3B, DNA (cytosine-5-)-methyltransferase 3 beta, DNA MTase HsaIIIB, DNA cytosine-5--methyltransferase 3 beta, DNA methyltransferase HsaIIIB
- HostRabbit
- IsotypeIgG
- Protein IDQ9UBC3
- Protein NameDNA (cytosine-5)-methyltransferase 3B
- Scientific DescriptionCpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase which is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes primarily to the nucleus and its expression is developmentally regulated. Mutations in this gene cause the immunodeficiency-centromeric instability-facial anomalies (ICF) syndrome. Six alternatively spliced transcript variants have been described. The full length sequences of variants 4 and 5 have not been determined. [provided by RefSeq]
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203
References
- Tu H, Zhang Z, Li J, et al. Loss of MEG3 contributes to the enhanced migration and invasion in arsenic-induced carcinogenesis through NQO1/FSCN1 pathway. Am J Cancer Res. 2023,13(6):2307-2322.Read this paper
- Wu YH, Huang YF, Wu PY, et al. The downregulation of miR-509-3p expression by collagen type XI alpha 1-regulated hypermethylation facilitates cancer progression and chemoresistance via the DNA methyltransferase 1/Small ubiquitin-like modifier-3 axis in ovarian cancer cells. J Ovarian Res. 2023,16(1):124. doi: 10.1186/s13048-023-01191-5Read this paper
- Wu YH, Huang YF, Wu PY, et al. The Downregulation of miR-509-3p Expression by Collagen Type XI Alpha 1-Regulated Hypermethylation Facilitates Cancer Progression and Chemoresistance via the DNA Methyltransferase 1/Small Ubiquitin-like Modifier-3 Axis in Ovarian Cancer Cells. Res Sq. 2023,:pii: rs.3.rs-2592453. doi: 10.21203/rs.3.rs-2592453/v1.Read this paper
- Xu J, Yang R, Li J, et al. DNMT3A/miR-129-2-5p/Rac1 Is an Effector Pathway for SNHG1 to Drive Stem-Cell-like and Invasive Behaviors of Advanced Bladder Cancer Cells. Cancers (Basel). 2022,14(17). doi: 10.3390/cancers14174159Read this paper
- Camero S, Vitali G, Pontecorvi P, et al. DNMT3A and DNMT3B Targeting as an Effective Radiosensitizing Strategy in Embryonal Rhabdomyosarcoma. Cells. 2021,10(11). doi: 10.3390/cells10112956Read this paper
- Williamson SM, Ingelson-Filpula WA, Hadj-Moussa H, et al. Epigenetic underpinnings of freeze avoidance in the goldenrod gall moth, Epiblema scudderiana. J Insect Physiol. 2021,134:104298. doi: 10.1016/j.jinsphys.2021.104298Read this paper
- Tessier SN, Ingelson-Filpula WA, Storey KB. Epigenetic regulation by DNA methyltransferases during torpor in the thirteen-lined ground squirrel Ictidomys tridecemlineatus. Mol Cell Biochem. 2021,476(11):3975-3985. doi: 10.1007/s11010-021-04214-1Read this paper
- Huang S, Hua X, Kuang M, et al. miR-190 promotes malignant transformation and progression of human urothelial cells through CDKN1B/p27 inhibition. Cancer Cell Int. 2021,21(1):241. doi: 10.1186/s12935-021-01937-5Read this paper
- Li J, Wang R, Jin J, et al. USP7 negatively controls global DNA methylation by attenuating ubiquitinated histone-dependent DNMT1 recruitment. Cell Discov. 2020,6:58. doi: 10.1038/s41421-020-00188-4Read this paper
- Yan JB, Lai CC, Jhu JW, et al. Insulin and Metformin Control Cell Proliferation by Regulating TDG-Mediated DNA Demethylation in Liver and Breast Cancer Cells. Mol Ther Oncolytics. 2020,18:282-294. doi: 10.1016/j.omto.2020.06.010Read this paper
Datasheet
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