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Doramapimod (GMP)

HY-10320G
MedChem Express
CAS Number285983-48-4
DownloadMSDS
Product group Chemicals
Molecular Weight527.66
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Overview

  • Supplier
    MedChem Express
  • Product Name
    Doramapimod (GMP) [285983-48-4]
  • Delivery Days Customer
    5
  • CAS Number
    285983-48-4
  • Certification
    Research Use Only
  • Molecular Formula
    C31H37N5O3
  • Molecular Weight
    527.66
  • Scientific Description
    Doramapimod GMP (BIRB 796 GMP) is an orally active inhibitor for p38 MAPK, with IC 50 s of 38, 65, 200 and 520 nM, for p38alpha, p38beta, p38gamma, p38delta. Doramapimod exhibits cytotoxicity and antitumor activity against multiple myeloma, synergizes with multidrug resistance protein 1 (ABCB1) and aurora kinase inhibitor VX680, promoting their antitumor efficacy against oral epidermoid carcinoma and cervical cancer. Doramapimod also exhibits anti-inflammatory activity [1] .
  • SMILES
    O=C(NC1=CC(C(C)(C)C)=NN1C2=CC=C(C)C=C2)NC3=C4C=CC=CC4=C(OCCN5CCOCC5)C=C3
  • UNSPSC
    12352200