Drosha antibody, Internal

GeneTex

Drosha antibody, Internal

9

This antibody also cross-reacts with human Ribonuclease III (GeneID 29102; NP_037367.2).

Western Blot

Research Use Only

Polyclonal

0.50 mg/ml

Unconjugated

DROSHA

drosha ribonuclease III

drosha, double-stranded RNA-specific endoribonuclease; ETOHI2; HSA242976; nuclear RNase III Drosha; p241; putative protein p241 which interacts with transcription factor Sp1; putative ribonuclease III; RANSE3L; ribonuclease 3; ribonuclease type III, nuclear; RN3; RNase III; RNASE3L; RNASEN

Goat

IgG

This gene encodes a ribonuclease (RNase) III double-stranded RNA-specific ribonuclease and subunit of the microprocessor protein complex, which catalyzes the initial processing step of microRNA (miRNA) synthesis. The encoded protein cleaves the stem loop structure from the primary microRNA (pri-miRNA) in the nucleus, yielding the precursor miRNA (pre-miRNA), which is then exported to the cytoplasm for further processing. In a human cell line lacking a functional copy of this gene, canonical miRNA synthesis is reduced. Somatic mutations in this gene have been observed in human patients with kidney cancer. [provided by RefSeq, Sep 2016]

Human, Mouse

2°C to 8°C,-20°C or -80°C

12352203