Dystrophin antibody [Dy4/6D3]

GeneTex

Dystrophin antibody [Dy4/6D3]

9

This antibody reacts strongly with the rod domain (between amino acids 1181 and 1388) of human dystrophin. No reactivity with mdx mouse tissue of DMD/BMD patients who have a gene deletion which removes the antibody binding site.,We do not recommend use of

ImmunoHistoChemistry, ImmunoHistoChemistry Frozen

Research Use Only

Monoclonal

Dy4/6D3

Unconjugated

DMD

dystrophin

BMD; CMD3B; DXS142; DXS164; DXS206; DXS230; DXS239; DXS268; DXS269; DXS270; DXS272; dystrophin; MRX85; truncated dystrophin

Mouse

IgG2a

This gene spans a genomic range of greater than 2 Mb and encodes a large protein containing an N-terminal actin-binding domain and multiple spectrin repeats. The encoded protein forms a component of the dystrophin-glycoprotein complex (DGC), which bridges the inner cytoskeleton and the extracellular matrix. Deletions, duplications, and point mutations at this gene locus may cause Duchenne muscular dystrophy (DMD), Becker muscular dystrophy (BMD), or cardiomyopathy. Alternative promoter usage and alternative splicing result in numerous distinct transcript variants and protein isoforms for this gene. [provided by RefSeq, Dec 2016]

Canine, Hamster, Human, Mouse, Porcine, Rabbit, Rat

2°C to 8°C,-20°C or -80°C

12352203