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E7 Antibody

CSB-PA361948LA01HMN
Cusabio
ApplicationsELISA
Product group Antibodies
ReactivityVirus
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Overview

  • Supplier
    Cusabio
  • Product Name
    E7 Antibody
  • Delivery Days Customer
    20
  • Applications
    ELISA
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Conjugate
    Unconjugated
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDP06788
  • Protein Name
    Protein E7
  • Scientific Description
    E7 protein has both transforming and trans-activating activities. Disrupts the function of host retinoblastoma protein RB1/pRb, which is a key regulator of the cell cycle. Induces the disassembly of the E2F1 transcription factors from RB1, with subsequent transcriptional activation of E2F1-regulated S-phase genes. Inactivation of the ability of RB1 to arrest the cell cycle is critical for cellular transformation, uncontrolled cellular growth and proliferation induced by viral infection. Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery to achieve viral genome replication. Interferes with histone deacetylation mediated by HDAC1 and HDAC2, leading to activation of transcription.
  • Reactivity
    Virus
  • Storage Instruction
    -20°C or -80°C
  • UNSPSC
    41116161

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