Western Blot analysis of Hela cells using EGFR Monoclonal Antibody at dilution of 1:1000.
Western Blot analysis of Hela cells using EGFR Monoclonal Antibody at dilution of 1:1000.
EGFR Monoclonal Antibody
E-AB-22007
Product group Antibodies
Overview
- SupplierElabscience
- Product NameEGFR Monoclonal Antibody
- Delivery Days Customer12
- CertificationResearch Use Only
- Scientific DescriptionReceptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, amphiregulin, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules. May also activate the NF-kappa-B signaling cascade. Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling. Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin.Isoform 2 may act as an antagonist of EGF action.
- UNSPSC12352203