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ProductsBack/EIF6 antibody [N1C3-2]

EIF6 antibody [N1C3-2]

GTX117971
GeneTex
ApplicationsWestern Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
TargetEIF6
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Overview

  • Supplier
    GeneTex
  • Product Name
    EIF6 antibody [N1C3-2]
  • Delivery Days Customer
    9
  • Application Supplier Note
    WB: 1:1000-1:10000. IHC-P: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    1.2 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID3692
  • Target name
    EIF6
  • Target description
    eukaryotic translation initiation factor 6
  • Target synonyms
    CAB, EIF3A, ITGB4BP, b(2)gcn, eIF-6, p27(BBP), p27BBP, eukaryotic translation initiation factor 6, B4 integrin interactor, eukaryotic translation initiation factor 3A, p27 beta-4 integrin-binding protein
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDP56537
  • Protein Name
    Eukaryotic translation initiation factor 6
  • Scientific Description
    Hemidesmosomes are structures which link the basal lamina to the intermediate filament cytoskeleton. An important functional component of hemidesmosomes is the integrin beta-4 subunit (ITGB4), a protein containing two fibronectin type III domains. The protein encoded by this gene binds to the fibronectin type III domains of ITGB4 and may help link ITGB4 to the intermediate filament cytoskeleton. The encoded protein, which is insoluble and found both in the nucleus and in the cytoplasm, can function as a translation initiation factor and prevent the association of the 40S and 60S ribosomal subunits. Multiple transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq]
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • Machado HE, Øbro NF, Williams N, et al. Convergent somatic evolution commences in utero in a germline ribosomopathy. Nat Commun. 2023,14(1):5092. doi: 10.1038/s41467-023-40896-5
    Read this paper
  • Tan S, Kermasson L, Hilcenko C, et al. Somatic genetic rescue of a germline ribosome assembly defect. Nat Commun. 2021,12(1):5044. doi: 10.1038/s41467-021-24999-5
    Read this paper

Datasheet

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