Bio-Connect

Estrogen Receptor beta antibody [6B12]

GTX70180
GeneTex
ApplicationsWestern Blot
Product group Antibodies
ReactivityHuman
TargetESR2
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Overview

  • Supplier
    GeneTex
  • Product Name
    Estrogen Receptor beta antibody [6B12]
  • Delivery Days Customer
    9
  • Antibody Specificity
    6B12 is specific for human ER-beta.
  • Application Supplier Note
    WB: 1:500-1:3000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    Western Blot
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    6B12
  • Concentration
    1 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID2100
  • Target name
    ESR2
  • Target description
    estrogen receptor 2
  • Target synonyms
    Erb; ER-BETA; ESRB; ESR-BETA; ESTRB; estrogen receptor beta; estrogen receptor beta 4; estrogen receptor beta splice variant, ERbeta2delta7; estrogen receptor beta splice variant, ERbeta4delta7; estrogen receptor beta splice variant, ERbeta6; estrogen receptor beta splice variant, ERbeta6delta7; estrogen receptor beta splice variant, ERbeta7; estrogen receptor beta splice variant, ERbeta7delta7; estrogen receptor beta splice variant, ERbetaEx. 4L; estrogen receptor beta splice variant, ERbetaEx. 6L; NR3A2; nuclear receptor subfamily 3 group A member 2; ODG8; oestrogen receptor beta
  • Host
    Mouse
  • Isotype
    IgG1
  • Protein IDQ92731
  • Protein Name
    Estrogen receptor beta
  • Scientific Description
    This gene encodes a member of the family of estrogen receptors and superfamily of nuclear receptor transcription factors. The gene product contains an N-terminal DNA binding domain and C-terminal ligand binding domain and is localized to the nucleus, cytoplasm, and mitochondria. Upon binding to 17beta-estradiol or related ligands, the encoded protein forms homo- or hetero-dimers that interact with specific DNA sequences to activate transcription. Some isoforms dominantly inhibit the activity of other estrogen receptor family members. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been fully characterized. [provided by RefSeq, Jul 2008]
  • Reactivity
    Human
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • Testosterone dependent androgen receptor stabilization and activation of cell proliferation in primary human myometrial microvascular endothelial cells. Dietrich W et al., 2011 Mar 15, Fertil Steril
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  • The estrogen metabolite 17beta-dihydroequilenin counteracts interleukin-1alpha induced expression of inflammatory mediators in human endothelial cells in vitro via NF-kappaB pathway. Demyanets S et al., 2006 Jan, Thromb Haemost
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  • Differential regulation of proteasome-dependent estrogen receptor alpha and beta turnover in cultured human uterine artery endothelial cells. Tschugguel W et al., 2003 May, J Clin Endocrinol Metab
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  • Identification of estrogen and progesterone receptor mRNA expression in the conjunctiva of premenopausal women. Fuchsjaeger-Mayrl G et al., 2002 Sep, Invest Ophthalmol Vis Sci
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