
ICC/IF analysis of HeLa cells using GTX24803 FAK (phospho Tyr397) antibody. Green : Primary antibody Blue : cell nucleus Fixation/Permeabilization : ice-cold 95% methanol
FAK (phospho Tyr397) antibody
GTX24803
ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ChIP Chromatin ImmunoPrecipitation, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen
Product group Antibodies
ReactivityAmphibian, Canine, Chicken, Drosophila, Feline, Fish, Human, Mouse, Primate, Rat, Xenopus, Zebra Fish
TargetPTK2
Overview
- SupplierGeneTex
- Product NameFAK (phospho Tyr397) antibody
- Delivery Days Customer9
- ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ChIP Chromatin ImmunoPrecipitation, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen
- CertificationResearch Use Only
- ClonalityPolyclonal
- ConjugateUnconjugated
- Gene ID5747
- Target namePTK2
- Target descriptionprotein tyrosine kinase 2
- Target synonymsFADK, FADK 1, FAK, FAK1, FRNK, PPP1R71, p125FAK, pp125FAK, focal adhesion kinase 1, FAK-related non-kinase polypeptide, PTK2 protein tyrosine kinase 2, focal adhesion kinase-related nonkinase, protein phosphatase 1 regulatory subunit 71
- HostRabbit
- IsotypeIgG
- Protein IDQ05397
- Protein NameFocal adhesion kinase 1
- Scientific DescriptionThis gene encodes a cytoplasmic protein tyrosine kinase which is found concentrated in the focal adhesions that form between cells growing in the presence of extracellular matrix constituents. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Activation of this gene may be an important early step in cell growth and intracellular signal transduction pathways triggered in response to certain neural peptides or to cell interactions with the extracellular matrix. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2017]
- ReactivityAmphibian, Canine, Chicken, Drosophila, Feline, Fish, Human, Mouse, Primate, Rat, Xenopus, Zebra Fish
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203
References
- Kuroda J, Itabashi T, Iwane AH, et al. The Physical Role of Mesenchymal Cells Driven by the Actin Cytoskeleton Is Essential for the Orientation of Collagen Fibrils in Zebrafish Fins. Front Cell Dev Biol. 2020,8:580520. doi: 10.3389/fcell.2020.580520Read this paper
- Terasaki M, Mima M, Kudoh S, et al. Glycine and succinic acid are effective indicators of the suppression of epithelial-mesenchymal transition by fucoxanthinol in colorectal cancer stem-like cells. Oncol Rep. 2018,40(1):414-424. doi: 10.3892/or.2018.6398Read this paper
- Liu CC, Lin SP, Hsu HS, et al. Suspension survival mediated by PP2A-STAT3-Col XVII determines tumour initiation and metastasis in cancer stem cells. Nat Commun. 2016,7:11798. doi: 10.1038/ncomms11798Read this paper
- McAndrews KM, McGrail DJ, Ravikumar N, et al. Mesenchymal Stem Cells Induce Directional Migration of Invasive Breast Cancer Cells through TGF-β. Sci Rep. 2015,5:16941. doi: 10.1038/srep16941Read this paper
- McGrail DJ, Khambhati NN, Qi MX, et al. Alterations in ovarian cancer cell adhesion drive taxol resistance by increasing microtubule dynamics in a FAK-dependent manner. Sci Rep. 2015,5:9529. doi: 10.1038/srep09529Read this paper
- Hsu HY, Lin JH, Li CJ, et al. Antimigratory Effects of the Methanol Extract from Momordica charantia on Human Lung Adenocarcinoma CL1 Cells. Evid Based Complement Alternat Med. 2012,2012:819632. doi: 10.1155/2012/819632Read this paper









