Fas antibody [ZB4]

GeneTex

Fas antibody [ZB4]

9

This antibody has been demonstrated to block the apoptotic activity of other anti-CD95 antibodies that are known to induce apoptosis.

FACS: Use at a concentration of 5 - 20 microg/ml. FuncS: Use at a concentration of 500 ng/ml to block the apoptotic activity other anti-CD95 antibodies. IHC: Use at an assay dependent dilution. WB: Use at a concentration of 5 microg/ml. Predicted molecular weight: 44 kDa. Optimal dilutions/concentrations should be determined by the end user.

Flow Cytometry, Western Blot, ImmunoHistoChemistry, Neutralisation/Blocking, Other Application

Research Use Only

Monoclonal

ZB4

1 mg/ml

Unconjugated

Liquid

FAS

Fas cell surface death receptor

ALPS1A; APO-1; APO-1 cell surface antigen; apoptosis antigen 1; apoptosis signaling receptor FAS; apoptosis-mediating surface antigen FAS; APT1; CD95; CD95 antigen; Fas (TNF receptor superfamily, member 6); Fas AMA; FAS1; FASLG receptor; FASTM; mutant tumor necrosis receptor superfamily member 6; TNF receptor superfamily member 6; TNFRSF6; tumor necrosis factor receptor superfamily member 6; tumor necrosis factor receptor superfamily, member 6

Mouse

IgG1

Tumor necrosis factor receptor superfamily member 6

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of this receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10. The autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade, and leads to apoptosis. This receptor has been also shown to activate NF-kappaB, MAPK3/ERK1, and MAPK8/JNK, and is found to be involved in transducing the proliferating signals in normal diploid fibroblast and T cells. Several alternatively spliced transcript variants have been described, some of which are candidates for nonsense-mediated mRNA decay (NMD). The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full length isoform. [provided by RefSeq, Mar 2011]

Human

-20°C or -80°C,2°C to 8°C

12352203