The data was published in the journal J Allergy Clin Immunol in 2017.PMID: 27913303
The data was published in the journal J Allergy Clin Immunol in 2017.PMID: 27913303
Filaggrin antibody [FLG01]
GTX23137
ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman, Mouse
TargetFLG
Overview
- SupplierGeneTex
- Product NameFilaggrin antibody [FLG01]
- Delivery Days Customer9
- Application Supplier NoteImmunohistochemistry (formalin fixed paraffin embedded): use at a concentration of 2 - 4microg / ml for 30 min at RT. Optimal dilutions / concentrations should be determined by the end user. Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 min.
- ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone IDFLG01
- Concentration0.2 mg/ml
- ConjugateUnconjugated
- Gene ID2312
- Target nameFLG
- Target descriptionfilaggrin
- Target synonymsATOD2; epidermal filaggrin; filaggrin
- HostMouse
- IsotypeIgG1
- Protein IDP20930
- Protein NameFilaggrin
- Scientific DescriptionThe protein encoded by this gene is an intermediate filament-associated protein that aggregates keratin intermediate filaments in mammalian epidermis. It is initially synthesized as a polyprotein precursor, profilaggrin (consisting of multiple filaggrin units of 324 aa each), which is localized in keratohyalin granules, and is subsequently proteolytically processed into individual functional filaggrin molecules. Mutations in this gene are associated with ichthyosis vulgaris.[provided by RefSeq, Dec 2009]
- ReactivityHuman, Mouse
- Storage Instruction2°C to 8°C
- UNSPSC12352203
References
- Lithospermum erythrorhizon Alleviates Atopic Dermatitis-like Skin Lesions by Restoring Immune Balance and Skin Barrier Function in 2.4-Dinitrochlorobenzene-Induced NC/Nga Mice. Oh JS et al., 2021 Sep 15, NutrientsRead more
- Orchestrated control of filaggrin-actin scaffolds underpins cornification. Gutowska-Owsiak D et al., 2018 Apr 1, Cell Death DisRead more
- Eczema in Psoriatico: An Important Differential Diagnosis Between Chronic Allergic Contact Dermatitis and Psoriasis in Palmoplantar Localization. Kolesnik M et al., 2018 Jan 12, Acta Derm VenereolRead more
- A mechanistic target of rapamycin complex 1/2 (mTORC1)/V-Akt murine thymoma viral oncogene homolog 1 (AKT1)/cathepsin H axis controls filaggrin expression and processing in skin, a novel mechanism for skin barrier disruption in patients with atopic dermatitis. Naeem AS et al., 2017 Apr, J Allergy Clin ImmunolRead more
- Human eccrine sweat gland cells can reconstitute a stratified epidermis. Biedermann T et al., 2010 Aug, J Invest DermatolRead more