Filaggrin antibody

Name: Filaggrin antibody
SKU: GTX37695_G10
Availability: BackOrder

GTX37695

ApplicationsImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Product group Antibodies

ReactivityHuman, Mouse, Rat

TargetFLG

Overview

Supplier
GeneTex
Product Name
Filaggrin antibody
Delivery Days Customer
9
Application Supplier Note
IHC-P: 1:100-500 (based on 0.5 mg/ml). *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Applications
ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Certification
Research Use Only
Clonality
Polyclonal
Concentration
0.5 mg/ml
Conjugate
Unconjugated
Gene ID2312
Target name
FLG
Target description
filaggrin
Target synonyms
ATOD2, FLG-1, FLG1, filaggrin, epidermal filaggrin
Host
Rabbit
Isotype
IgG
Protein IDP20930
Protein Name
Filaggrin
Scientific Description
The protein encoded by this gene is an intermediate filament-associated protein that aggregates keratin intermediate filaments in mammalian epidermis. It is initially synthesized as a polyprotein precursor, profilaggrin (consisting of multiple filaggrin units of 324 aa each), which is localized in keratohyalin granules, and is subsequently proteolytically processed into individual functional filaggrin molecules. Mutations in this gene are associated with ichthyosis vulgaris.[provided by RefSeq, Dec 2009]
Reactivity
Human, Mouse, Rat
Storage Instruction
-20°C or -80°C,2°C to 8°C
UNSPSC
12352203

References

Kim SY, Lee JO, Kim YJ, et al. Effects of Oral Administration of Lactiplantibacillus Plantarum APsulloc 331261 (GTB1(TM)) Isolated from Green Tea on Atopic Dermatitis (AD)-like Skin Lesion Mouse Models. Evid Based Complement Alternat Med. 2022,2022:4520433. doi: 10.1155/2022/4520433
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Kim EY, Hong S, Kim JH, et al. Effects of chloroform fraction of Fritillariae Thunbergii Bulbus on atopic symptoms in a DNCB-induced atopic dermatitis-like skin lesion model and in vitro models. J Ethnopharmacol. 2021,281:114453. doi: 10.1016/j.jep.2021.114453
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Kitazawa K, Nadanaka S, Kadomatsu K, et al. Chondroitin 6-sulfate represses keratinocyte proliferation in mouse skin, which is associated with psoriasis. Commun Biol. 2021,4(1):114. doi: 10.1038/s42003-020-01618-5
Read this paper
Lee CW, Su YH, Chiang YC, et al. Glycofullerenes Inhibit Particulate Matter Induced Inflammation and Loss of Barrier Proteins in HaCaT Human Keratinocytes. Biomolecules. 2020,10(4). doi: 10.3390/biom10040514
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Kim SH, Seong GS, Choung SY. Fermented Morinda citrifolia (Noni) Alleviates DNCB-Induced Atopic Dermatitis in NC/Nga Mice through Modulating Immune Balance and Skin Barrier Function. Nutrients. 2020,12(1). doi: 10.3390/nu12010249
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Song C, Liu L, Chen J, et al. Evidence for the critical role of the PI3K signaling pathway in particulate matter-induced dysregulation of the inflammatory mediators COX-2/PGE(2) and the associated epithelial barrier protein Filaggrin in the bronchial epithelium. Cell Biol Toxicol. 2020,36(4):301-313. doi: 10.1007/s10565-019-09508-1
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Lee CW, Chi MC, Peng KT, et al. Water-Soluble Fullerenol C(60)(OH)(36) toward Effective Anti-Air Pollution Induced by Urban Particulate Matter in HaCaT Cell. Int J Mol Sci. 2019,20(17). doi: 10.3390/ijms20174259
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Kim KP, Jeon S, Kim MJ, et al. Borage oil restores acidic skin pH by up-regulating the activity or expression of filaggrin and enzymes involved in epidermal lactate, free fatty acid, and acidic free amino acid metabolism in essential fatty acid-deficient Guinea pigs. Nutr Res. 2018,58:26-35. doi: 10.1016/j.nutres.2018.06.003
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He K, Sakai T, Tsukasaki Y, et al. Myosin X is recruited to nascent focal adhesions at the leading edge and induces multi-cycle filopodial elongation. Sci Rep. 2017,7(1):13685. doi: 10.1038/s41598-017-06147-6
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Xiong Z, Ren S, Chen H, et al. PAX9 regulates squamous cell differentiation and carcinogenesis in the oro-oesophageal epithelium. J Pathol. 2018,244(2):164-175. doi: 10.1002/path.4998
Read this paper

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Filaggrin antibody

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