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ProductsBack/Filamin B antibody [N1], N-term

Filamin B antibody [N1], N-term

GTX101206
GeneTex
ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
DownloadDatasheet
Product group Antibodies
ReactivityHuman, Mouse
TargetFLNB
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Overview

  • Supplier
    GeneTex
  • Product Name
    Filamin B antibody [N1], N-term
  • Delivery Days Customer
    9
  • Application Supplier Note
    WB: 1:500-1:10000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    ImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    10 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID2317
  • Target name
    FLNB
  • Target description
    filamin B
  • Target synonyms
    ABP-278; ABP-280; ABP-280 homolog; actin binding protein 278; actin-binding-like protein; AOI; beta-filamin; FH1; filamin B, beta; filamin homolog 1; filamin-3; filamin-B; FLN1L; FLN-B; Larsen syndrome 1 (autosomal dominant); LRS1; SCT; TABP; TAP; thyroid autoantigen
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDO75369
  • Protein Name
    Filamin-B
  • Scientific Description
    This gene encodes a member of the filamin family. The encoded protein interacts with glycoprotein Ib alpha as part of the process to repair vascular injuries. The platelet glycoprotein Ib complex includes glycoprotein Ib alpha, and it binds the actin cytoskeleton. Mutations in this gene have been found in several conditions: atelosteogenesis type 1 and type 3; boomerang dysplasia; autosomal dominant Larsen syndrome; and spondylocarpotarsal synostosis syndrome. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq]
  • Reactivity
    Human, Mouse
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • Downregulation of Filamin a Expression in the Aorta Is Correlated With Aortic Dissection. Chen Y et al., 2021, Front Cardiovasc Med
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  • Mechanisms and Effects on HBV Replication of the Interaction between HBV Core Protein and Cellular Filamin B. Li Y et al., 2018 Apr, Virol Sin
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  • Filamin B Loss-of-Function Mutation in Dimerization Domain Causes Autosomal-Recessive Spondylocarpotarsal Synostosis Syndrome with Rib Anomalies. Yang CF et al., 2017 May, Hum Mutat
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  • Dense fibrillar collagen is a potent inducer of invadopodia via a specific signaling network. Artym VV et al., 2015 Feb 2, J Cell Biol
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