Filamin B antibody [N1], N-term
GTX101206
ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman, Mouse
TargetFLNB
Overview
- SupplierGeneTex
- Product NameFilamin B antibody [N1], N-term
- Delivery Days Customer9
- Application Supplier NoteWB: 1:500-1:10000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
- CertificationResearch Use Only
- ClonalityPolyclonal
- Concentration10 mg/ml
- ConjugateUnconjugated
- Gene ID2317
- Target nameFLNB
- Target descriptionfilamin B
- Target synonymsABP-278, ABP-280, AOI, FH1, FLN-B, FLN1L, LRS1, SCT, TABP, TAP, filamin-B, ABP-280 homolog, Larsen syndrome 1 (autosomal dominant), actin binding protein 278, actin-binding-like protein, beta-filamin, filamin B, beta, filamin homolog 1, filamin-3, thyroid autoantigen
- HostRabbit
- IsotypeIgG
- Protein IDO75369
- Protein NameFilamin-B
- Scientific DescriptionThis gene encodes a member of the filamin family. The encoded protein interacts with glycoprotein Ib alpha as part of the process to repair vascular injuries. The platelet glycoprotein Ib complex includes glycoprotein Ib alpha, and it binds the actin cytoskeleton. Mutations in this gene have been found in several conditions: atelosteogenesis type 1 and type 3; boomerang dysplasia; autosomal dominant Larsen syndrome; and spondylocarpotarsal synostosis syndrome. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq]
- ReactivityHuman, Mouse
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203
References
- Chen Y, Wei X, Zhang Z, et al. Downregulation of Filamin a Expression in the Aorta Is Correlated With Aortic Dissection. Front Cardiovasc Med. 2021,8:690846. doi: 10.3389/fcvm.2021.690846Read this paper
- Li Y, Sun Y, Sun F, et al. Mechanisms and Effects on HBV Replication of the Interaction between HBV Core Protein and Cellular Filamin B. Virol Sin. 2018,33(2):162-172. doi: 10.1007/s12250-018-0023-4Read this paper
- Yang CF, Wang CH, Siong H'ng W, et al. Filamin B Loss-of-Function Mutation in Dimerization Domain Causes Autosomal-Recessive Spondylocarpotarsal Synostosis Syndrome with Rib Anomalies. Hum Mutat. 2017,38(5):540-547. doi: 10.1002/humu.23186Read this paper
- Artym VV, Swatkoski S, Matsumoto K, et al. Dense fibrillar collagen is a potent inducer of invadopodia via a specific signaling network. J Cell Biol. 2015,208(3):331-50. doi: 10.1083/jcb.201405099Read this paper




