FLT3 antibody [BV10A4]

GeneTex

FLT3 antibody [BV10A4]

9

We do not recommend use of this product for Mouse.

Flow Cytometry, ImmunoPrecipitation

Research Use Only

Monoclonal

BV10A4

1 mg/ml

Unconjugated

FLT3

fms related receptor tyrosine kinase 3

CD135; CD135 antigen; fetal liver kinase 2; FL cytokine receptor; FLK2; FLK-2; fms related tyrosine kinase 3; fms-like tyrosine kinase 3; growth factor receptor tyrosine kinase type III; receptor-type tyrosine-protein kinase FLT3; stem cell tyrosine kinase 1; STK1

Mouse

IgG1

Receptor-type tyrosine-protein kinase FLT3

This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. This receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia. [provided by RefSeq, Jan 2015]

Human

2°C to 8°C

12352203