FLT3 Antibody

Aviva Systems Biology

FLT3 Antibody

23

WB: 1:500 - 1:2,000. IHC: 1:50 - 1:100

Western Blot, ImmunoHistoChemistry

Research Use Only

Polyclonal

Unconjugated

Liquid

FLT3

fms related receptor tyrosine kinase 3

CD135, FLK-2, FLK2, STK1, receptor-type tyrosine-protein kinase FLT3, CD135 antigen, FL cytokine receptor, fetal liver kinase 2, fms related tyrosine kinase 3, fms-like tyrosine kinase 3, growth factor receptor tyrosine kinase type III, stem cell tyrosine kinase 1

Rabbit

IgG

Receptor-type tyrosine-protein kinase FLT3

This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. This receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia.

Human, Mouse, Rat

-20°C

41116161