FOXA1 antibody

Name: FOXA1 antibody
SKU: GTX100308_G10
Availability: BackOrder

GTX100308

ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ChIP Chromatin ImmunoPrecipitation, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Product group Antibodies

TargetFOXA1

Overview

Supplier
GeneTex
Product Name
FOXA1 antibody
Delivery Days Customer
9
Application Supplier Note
WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. IP: 1:100-1:500. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Applications
ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ChIP Chromatin ImmunoPrecipitation, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Certification
Research Use Only
Clonality
Polyclonal
Concentration
0.44 mg/ml
Conjugate
Unconjugated
Gene ID3169
Target name
FOXA1
Target description
forkhead box A1
Target synonyms
HNF3A, TCF3A, hepatocyte nuclear factor 3-alpha, HNF-3-alpha, HNF-3A, TCF-3A, forkhead box protein A1, transcription factor 3A
Host
Rabbit
Isotype
IgG
Protein IDP55317
Protein Name
Hepatocyte nuclear factor 3-alpha
Scientific Description
This gene encodes a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific transcripts such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver. [provided by RefSeq]
Storage Instruction
-20°C or -80°C,2°C to 8°C
UNSPSC
12352203

References

Xu L, Ma X, Zhang X, et al. hsa_circ_0007919 induces LIG1 transcription by binding to FOXA1/TET1 to enhance the DNA damage response and promote gemcitabine resistance in pancreatic ductal adenocarcinoma. Mol Cancer. 2023,22(1):195. doi: 10.1186/s12943-023-01887-8
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Xu C, Kleinschmidt H, Yang J, et al. Systematic Dissection of Sequence Features Affecting the Binding Specificity of a Pioneer Factor Reveals Binding Synergy Between FOXA1 and AP-1. bioRxiv. 2023,:pii: 2023.11.08.566246. doi: 10.1101/2023.11.08.566246.
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Lemma RB, Fleischer T, Martinsen E, et al. Pioneer transcription factors are associated with the modulation of DNA methylation patterns across cancers. Epigenetics Chromatin. 2022,15(1):13. doi: 10.1186/s13072-022-00444-9
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Detilleux D, Spill YG, Balaramane D, et al. Pan-cancer predictions of transcription factors mediating aberrant DNA methylation. Epigenetics Chromatin. 2022,15(1):10. doi: 10.1186/s13072-022-00443-w
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Wang X, Lai F, Xiong J, et al. DNA methylation modification is associated with gonadal differentiation in Monopterus albus. Cell Biosci. 2020,10(1):129. doi: 10.1186/s13578-020-00490-4
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Lin ZS, Chung CC, Liu YC, et al. FOXA1 transcriptionally up-regulates cyclin B1 expression to enhance chondrosarcoma progression. Am J Cancer Res. 2018,8(10):1989-2004.
Read this paper
Sundararaman B, Zhan L, Blue SM, et al. Resources for the Comprehensive Discovery of Functional RNA Elements. Mol Cell. 2016,61(6):903-13. doi: 10.1016/j.molcel.2016.02.012
Read this paper

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FOXA1 antibody

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