FZR1 Antibody, FITC conjugated

Cusabio

FZR1 Antibody, FITC conjugated

20

Research Use Only

Polyclonal

FITC

FZR1

fizzy and cell division cycle 20 related 1

CDC20C, CDH1, DEE109, FZR, FZR2, HCDH, HCDH1, fizzy-related protein homolog, CDC20 homolog 1, CDC20-like 1b, CDC20-like protein 1, cdh1/Hct1 homolog, fizzy/cell division cycle 20 related 1

Rabbit

IgG

Fizzy-related protein homolog

Key regulator of ligase activity of the anaphase promoting complex/cyclosome (APC/C), which confers substrate specificity upon the complex. Associates with the APC/C in late mitosis, in replacement of CDC20, and activates the APC/C during anaphase and telophase. The APC/C remains active in degrading substrates to ensure that positive regulators of the cell cycle do not accumulate prematurely. At the G1/S transition FZR1 is phosphorylated, leading to its dissociation from the APC/C. Following DNA damage, it is required for the G2 DNA damage checkpoint: its dephosphorylation and reassociation with the APC/C leads to the ubiquitination of PLK1, preventing entry into mitosis.

Human

-20°C or -80°C

41116161