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G9a antibody

GTX129153
GeneTex
ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ChIP Chromatin ImmunoPrecipitation, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman, Mouse, Rat
TargetEHMT2
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Overview

  • Supplier
    GeneTex
  • Product Name
    G9a antibody
  • Delivery Days Customer
    9
  • Application Supplier Note
    WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. IP: 1:100-1:500. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ChIP Chromatin ImmunoPrecipitation, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    1.34 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID10919
  • Target name
    EHMT2
  • Target description
    euchromatic histone lysine methyltransferase 2
  • Target synonyms
    ankyrin repeat-containing protein; BAT8; C6orf30; euchromatic histone-lysine N-methyltransferase 2; G9A; G9A histone methyltransferase; GAT8; H3-K9-HMTase 3; histone H3-K9 methyltransferase 3; histone-lysine N-methyltransferase EHMT2; histone-lysine N-methyltransferase, H3 lysine-9 specific 3; HLA-B associated transcript 8; KMT1C; lysine N-methyltransferase 1C; NG36
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDQ96KQ7
  • Protein Name
    Histone-lysine N-methyltransferase EHMT2
  • Scientific Description
    This gene encodes a methyltransferase that methylates lysine residues of histone H3. Methylation of H3 at lysine 9 by this protein results in recruitment of additional epigenetic regulators and repression of transcription. This gene was initially thought to be two different genes, NG36 and G9a, adjacent to each other in the HLA locus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
  • Reactivity
    Human, Mouse, Rat
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • H3K9me2 regulation of BDNF expression via G9a partakes in the progression of heart failure. Yan F et al., 2022 Apr 19, BMC Cardiovasc Disord
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  • Epigenetic therapy combination of UNC0638 and CI-994 suppresses breast cancer via epigenetic remodeling of BIRC5 and GADD45A. Lin HY et al., 2022 Jan, Biomed Pharmacother
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  • Targeting histone methyltransferase G9a inhibits growth and Wnt signaling pathway by epigenetically regulating HP1alpha and APC2 gene expression in non-small cell lung cancer. Zhang K et al., 2018 Oct 22, Mol Cancer
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  • Preprogramming therapeutic response of PI3K/mTOR dual inhibitor via the regulation of EHMT2 and p27 in pancreatic cancer. Tian YF et al., 2018, Am J Cancer Res
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  • G9a governs colon cancer stem cell phenotype and chemoradioresistance through PP2A-RPA axis-mediated DNA damage response. Luo CW et al., 2017 Sep, Radiother Oncol
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