GAD67 antibody [GAD1/2391]

GeneTex

GAD67 antibody [GAD1/2391]

9

WB: 1-2microg/ml. IHC-P: 1-2microg/ml for 30 minutes at RT. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

Western Blot, ELISA, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin, Other Application

Research Use Only

Monoclonal

GAD1/2391

0.2 mg/ml

Unconjugated

Liquid

GAD1

glutamate decarboxylase 1

67 kDa glutamic acid decarboxylase; CPSQ1; DEE89; GAD; GAD-67; glutamate decarboxylase 1; glutamate decarboxylase 1 (brain, 67kDa); SCP

Mouse

IgG1

Glutamate decarboxylase 1

This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantigen and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Deficiency in this enzyme has been shown to lead to pyridoxine dependency with seizures. Alternative splicing of this gene results in two products, the predominant 67-kD form and a less-frequent 25-kD form. [provided by RefSeq, Jul 2008]

Human

-20°C or -80°C,2°C to 8°C

12352203