Bio-Connect

GADD153 antibody [N1C3]

GTX112827
GeneTex
ApplicationsWestern Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman, Mouse, Rat
TargetDDIT3
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Overview

  • Supplier
    GeneTex
  • Product Name
    GADD153 antibody [N1C3]
  • Delivery Days Customer
    9
  • Application Supplier Note
    WB: 1:500-1:3000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    1.3 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID1649
  • Target name
    DDIT3
  • Target description
    DNA damage inducible transcript 3
  • Target synonyms
    AltDDIT3, C/EBPzeta, CEBPZ, CHOP, CHOP-10, CHOP10, GADD153, DNA damage-inducible transcript 3 protein, C/EBP zeta, CCAAT/enhancer-binding protein homologous protein, alternative DDIT3 protein, c/EBP-homologous protein 10, growth arrest and DNA damage-inducible protein GADD153
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDP35638
  • Protein Name
    DNA damage-inducible transcript 3 protein
  • Scientific Description
    This gene encodes a member of the CCAAT/enhancer-binding protein (C/EBP) family of transcription factors. The protein functions as a dominant-negative inhibitor by forming heterodimers with other C/EBP members, such as C/EBP and LAP (liver activator protein), and preventing their DNA binding activity. The protein is implicated in adipogenesis and erythropoiesis, is activated by endoplasmic reticulum stress, and promotes apoptosis. Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in myxoid liposarcomas or Ewing sarcoma. Multiple alternatively spliced transcript variants encoding two isoforms with different length have been identified. [provided by RefSeq]
  • Reactivity
    Human, Mouse, Rat
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

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  • Huang CY, Deng JS, Huang WC, et al. Attenuation of Lipopolysaccharide-Induced Acute Lung Injury by Hispolon in Mice, Through Regulating the TLR4/PI3K/Akt/mTOR and Keap1/Nrf2/HO-1 Pathways, and Suppressing Oxidative Stress-Mediated ER Stress-Induced Apoptosis and Autophagy. Nutrients. 2020,12(6). doi: 10.3390/nu12061742
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  • Chen JF, Tsai YT, Lai YH, et al. Proteomic analysis of Antrodia Cinnamomea-induced ER stress in liver cancer cells. J Pharm Biomed Anal. 2020,187:113142. doi: 10.1016/j.jpba.2020.113142
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  • Rauti R, Qaisiya M, Tiribelli C, et al. Bilirubin disrupts calcium homeostasis in neonatal hippocampal neurons: a new pathway of neurotoxicity. Arch Toxicol. 2020,94(3):845-855. doi: 10.1007/s00204-020-02659-9
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  • Zhu R, Li X, Xu J, et al. Defective endoplasmic reticulum export causes proinsulin misfolding in pancreatic β cells. Mol Cell Endocrinol. 2019,493:110470. doi: 10.1016/j.mce.2019.110470
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  • Li JF, Li YS, Zhang YY, et al. Regulation of P300 and HDAC1 on endoplasmic reticulum stress in isoniazid-induced HL-7702 hepatocyte injury. J Cell Physiol. 2019,234(9):15299-15307. doi: 10.1002/jcp.28175
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  • Lin S, Yang L, Shi H, et al. Endoplasmic reticulum-targeting photosensitizer Hypericin confers chemo-sensitization towards oxaliplatin through inducing pro-death autophagy. Int J Biochem Cell Biol. 2017,87:54-68. doi: 10.1016/j.biocel.2017.04.001
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  • Chiang MC, Cheng YC, Nicol CJ, et al. Rosiglitazone activation of PPARγ-dependent signaling is neuroprotective in mutant huntingtin expressing cells. Exp Cell Res. 2015,338(2):183-93. doi: 10.1016/j.yexcr.2015.09.005
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  • Karam R, Lou CH, Kroeger H, et al. The unfolded protein response is shaped by the NMD pathway. EMBO Rep. 2015,16(5):599-609. doi: 10.15252/embr.201439696
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  • Lin S, Zhang L, Lei K, et al. Development of a multifunctional luciferase reporters system for assessing endoplasmic reticulum-targeting photosensitive compounds. Cell Stress Chaperones. 2014,19(6):927-37. doi: 10.1007/s12192-014-0517-4
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