Ganglioside GM2, Asialo

MedChem Express

Ganglioside GM2, Asialo [35960-33-9]

10

35960-33-9

Research Use Only

C56H104N2O18

1093.43

Ganglioside GM2 asialo (asialo-GM2) is a glycosphingolipid containing three monosaccharide residues and one fatty acid of variable chain length, but lacks the sialic acid residue present on ganglioside M2. Asialo-GM2 is found at low or undetectable levels in normal human brains, but it accumulates in the brains of patients with Tay-Sachs disease and Sandhoff disease, which are expressed as lysosomal beta- A neurodegenerative disorder characterized by hexosaminidase A and B deficiency. It also binds to various bacteria, including Pseudomonas isolated from cystic fibrosis patients. The Asialo-GM2 mixture contains ganglioside GM2 asialo molecular species with fatty acyl chains of variable length.

CCCCCCCCCCCCCCCCCC(N[C@H]([C@H](O)/C=C/CCCCCCCCCCCCC)CO[C@H]1C(O)C(O)[C@H](O[C@H]2C(O)[C@@H](O)[C@@H](O[C@@H]3C(NC(C)=O)C(O)[C@@H](O)[C@@H](O3)CO)C(O2)CO)[C@@H](O1)CO)=O

2°C to 8°C

12352200