Bio-Connect

Grp78 antibody [N2C1], Internal

GTX102580
GeneTex
ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman, Insect, Mouse, Rat, Zebra Fish
TargetHSPA5
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Overview

  • Supplier
    GeneTex
  • Product Name
    Grp78 antibody [N2C1], Internal
  • Delivery Days Customer
    9
  • Antibody Specificity
    Knockdown/Knockout validation was supported by customer review data.
  • Application Supplier Note
    WB: 1:1000-1:10000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. IP: 1:100-1:500. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    1.28 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID3309
  • Target name
    HSPA5
  • Target description
    heat shock protein family A (Hsp70) member 5
  • Target synonyms
    78 kDa glucose-regulated protein; binding-immunoglobulin protein; BIP; endoplasmic reticulum chaperone BiP; endoplasmic reticulum lumenal Ca(2+)-binding protein grp78; epididymis secretory sperm binding protein Li 89n; glucose-regulated protein, 78kDa; GRP78; heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa); heat shock protein 70 family protein 5; heat shock protein family A member 5; HEL-S-89n; HSP70 family protein 5; immunoglobulin heavy chain-binding protein
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDP11021
  • Protein Name
    Endoplasmic reticulum chaperone BiP
  • Scientific Description
    When Chinese hamster K12 cells are starved of glucose, the synthesis of several proteins, called glucose-regulated proteins (GRPs), is markedly increased. Hendershot et al. (1994) [PubMed 8020977] pointed out that one of these, GRP78 (HSPA5), also referred to as immunoglobulin heavy chain-binding protein (BiP), is a member of the heat-shock protein-70 (HSP70) family and is involved in the folding and assembly of proteins in the endoplasmic reticulum (ER). Because so many ER proteins interact transiently with GRP78, it may play a key role in monitoring protein transport through the cell.[supplied by OMIM]
  • Reactivity
    Human, Insect, Mouse, Rat, Zebra Fish
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • Placental Alkaline Phosphatase Promotes Zika Virus Replication by Stabilizing Viral Proteins through BIP. Chen J et al., 2020 Sep 15, mBio
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  • The unfolded protein response modulates the autophagy-mediated egg production in the mosquito Aedes aegypti. Weng SC et al., 2020 Aug, Insect Mol Biol
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  • Metformin attenuates the D-galactose-induced aging process via the UPR through the AMPK/ERK1/2 signaling pathways. Cai H et al., 2020 Mar, Int J Mol Med
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  • The role of sodium hydrosulfide in attenuating the aging process via PI3K/AKT and CaMKKbeta/AMPK pathways. Chen X et al., 2017 Aug, Redox Biol
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  • Periodontal disease level-butyric acid amounts locally administered in the rat gingival mucosa induce ER stress in the systemic blood. Cueno ME et al., 2016 May, Microb Pathog
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