GRP94 antibody
GTX103232
ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman, Mouse, Rat
TargetHSP90B1
Overview
- SupplierGeneTex
- Product NameGRP94 antibody
- Delivery Days Customer9
- Application Supplier NoteWB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. IP: 1:100-1:500. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
- CertificationResearch Use Only
- ClonalityPolyclonal
- Concentration1 mg/ml
- ConjugateUnconjugated
- Gene ID7184
- Target nameHSP90B1
- Target descriptionheat shock protein 90 beta family member 1
- Target synonymsECGP, GP96, GRP94, HEL-S-125m, HEL35, TRA1, endoplasmin, 94 kDa glucose-regulated protein, endothelial cell (HBMEC) glycoprotein, epididymis luminal protein 35, epididymis secretory sperm binding protein Li 125m, heat shock protein 90 kDa beta member 1, heat shock protein 90kDa beta (Grp94), member 1, heat shock protein 90kDa beta family member 1, heat shock protein family C member 4, stress-inducible tumor rejection antigen gp96, tumor rejection antigen (gp96) 1, tumor rejection antigen 1
- HostRabbit
- IsotypeIgG
- Protein IDP14625
- Protein NameEndoplasmin
- Scientific DescriptionHSP90 proteins are highly conserved molecular chaperones that have key roles in signal transduction, protein folding, protein degradation, and morphologic evolution. HSP90 proteins normally associate with other cochaperones and play important roles in folding newly synthesized proteins or stabilizing and refolding denatured proteins after stress. HSP90B1 is an endoplasmic reticulum HSP90 protein. Other HSP90 proteins are found in cytosol (see HSP90AA1; MIM 140571) and mitochondria (TRAP1; MIM 606219) (Chen et al., 2005 [PubMed 16269234]).[supplied by OMIM]
- ReactivityHuman, Mouse, Rat
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203
References
- Chua HH, Chang MH, Chen YH, et al. PIM1-Induced Cytoplasmic Expression of RBMY Mediates Hepatocellular Carcinoma Metastasis. Cell Mol Gastroenterol Hepatol. 2023,15(1):121-152. doi: 10.1016/j.jcmgh.2022.09.014Read this paper
- Chen HH, Yu HI, Rudy R, et al. DDX3 modulates the tumor microenvironment via its role in endoplasmic reticulum-associated translation. iScience. 2021,24(9):103086. doi: 10.1016/j.isci.2021.103086Read this paper
- Brzozowa-Zasada M, Kurek J, Piecuch A, et al. The clinical and prognostic evaluation of GRP94 immunoexpression in Caucasian patients with colorectal adenocarcinoma. Prz Gastroenterol. 2019,14(2):140-147. doi: 10.5114/pg.2019.85898Read this paper
- Domenis R, Cifù A, Marinò D, et al. Toll-like Receptor-4 Activation Boosts the Immunosuppressive Properties of Tumor Cells-derived Exosomes. Sci Rep. 2019,9(1):8457. doi: 10.1038/s41598-019-44949-yRead this paper
- Xiao X, Li S, Zhang X, et al. HHQ-4, a quinoline derivate, preferentially inhibits proliferation of glucose-deprived breast cancer cells as a GRP78 down-regulator. Toxicol Appl Pharmacol. 2019,373:10-25. doi: 10.1016/j.taap.2019.04.017Read this paper
- Lee CW, Chi MC, Chang TM, et al. Artocarpin induces cell apoptosis in human osteosarcoma cells through endoplasmic reticulum stress and reactive oxygen species. J Cell Physiol. 2019,234(8):13157-13168. doi: 10.1002/jcp.27986Read this paper
- Domenis R, Cifù A, Quaglia S, et al. Pro inflammatory stimuli enhance the immunosuppressive functions of adipose mesenchymal stem cells-derived exosomes. Sci Rep. 2018,8(1):13325. doi: 10.1038/s41598-018-31707-9Read this paper
- Zadoo S, Nguyen A, Zode G, et al. A Novel Luciferase Assay For Sensitively Monitoring Myocilin Variants in Cell Culture. Invest Ophthalmol Vis Sci. 2016,57(4):1939-50. doi: 10.1167/iovs.15-18789Read this paper
- Chen DJ, Xu YM, Zheng W, et al. Proteomic analysis of secreted proteins by human bronchial epithelial cells in response to cadmium toxicity. Proteomics. 2015,15(17):3075-86. doi: 10.1002/pmic.201400489Read this paper
- Boso G, Somia NV. Characterization of resistance to rhabdovirus and retrovirus infection in a human myeloid cell line. PLoS One. 2015,10(3):e0121455. doi: 10.1371/journal.pone.0121455Read this paper



![IHC-P analysis of human breast carcinoma tissue using GTX34773 GRP94 antibody [HSP90B1/1192].](https://www.genetex.com/upload/website/prouct_img/normal/GTX34773/GTX34773_20200115_IHC-P_358_w_23060801_277.webp)
