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GRP94 antibody

GTX103232
GeneTex
ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman, Mouse, Rat
TargetHSP90B1
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Overview

  • Supplier
    GeneTex
  • Product Name
    GRP94 antibody
  • Delivery Days Customer
    9
  • Application Supplier Note
    WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. IP: 1:100-1:500. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    1 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID7184
  • Target name
    HSP90B1
  • Target description
    heat shock protein 90 beta family member 1
  • Target synonyms
    ECGP, GP96, GRP94, HEL-S-125m, HEL35, TRA1, endoplasmin, 94 kDa glucose-regulated protein, endothelial cell (HBMEC) glycoprotein, epididymis luminal protein 35, epididymis secretory sperm binding protein Li 125m, heat shock protein 90 kDa beta member 1, heat shock protein 90kDa beta (Grp94), member 1, heat shock protein 90kDa beta family member 1, heat shock protein family C member 4, stress-inducible tumor rejection antigen gp96, tumor rejection antigen (gp96) 1, tumor rejection antigen 1
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDP14625
  • Protein Name
    Endoplasmin
  • Scientific Description
    HSP90 proteins are highly conserved molecular chaperones that have key roles in signal transduction, protein folding, protein degradation, and morphologic evolution. HSP90 proteins normally associate with other cochaperones and play important roles in folding newly synthesized proteins or stabilizing and refolding denatured proteins after stress. HSP90B1 is an endoplasmic reticulum HSP90 protein. Other HSP90 proteins are found in cytosol (see HSP90AA1; MIM 140571) and mitochondria (TRAP1; MIM 606219) (Chen et al., 2005 [PubMed 16269234]).[supplied by OMIM]
  • Reactivity
    Human, Mouse, Rat
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • Chua HH, Chang MH, Chen YH, et al. PIM1-Induced Cytoplasmic Expression of RBMY Mediates Hepatocellular Carcinoma Metastasis. Cell Mol Gastroenterol Hepatol. 2023,15(1):121-152. doi: 10.1016/j.jcmgh.2022.09.014
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  • Chen HH, Yu HI, Rudy R, et al. DDX3 modulates the tumor microenvironment via its role in endoplasmic reticulum-associated translation. iScience. 2021,24(9):103086. doi: 10.1016/j.isci.2021.103086
    Read this paper
  • Brzozowa-Zasada M, Kurek J, Piecuch A, et al. The clinical and prognostic evaluation of GRP94 immunoexpression in Caucasian patients with colorectal adenocarcinoma. Prz Gastroenterol. 2019,14(2):140-147. doi: 10.5114/pg.2019.85898
    Read this paper
  • Domenis R, Cifù A, Marinò D, et al. Toll-like Receptor-4 Activation Boosts the Immunosuppressive Properties of Tumor Cells-derived Exosomes. Sci Rep. 2019,9(1):8457. doi: 10.1038/s41598-019-44949-y
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  • Xiao X, Li S, Zhang X, et al. HHQ-4, a quinoline derivate, preferentially inhibits proliferation of glucose-deprived breast cancer cells as a GRP78 down-regulator. Toxicol Appl Pharmacol. 2019,373:10-25. doi: 10.1016/j.taap.2019.04.017
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  • Lee CW, Chi MC, Chang TM, et al. Artocarpin induces cell apoptosis in human osteosarcoma cells through endoplasmic reticulum stress and reactive oxygen species. J Cell Physiol. 2019,234(8):13157-13168. doi: 10.1002/jcp.27986
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  • Domenis R, Cifù A, Quaglia S, et al. Pro inflammatory stimuli enhance the immunosuppressive functions of adipose mesenchymal stem cells-derived exosomes. Sci Rep. 2018,8(1):13325. doi: 10.1038/s41598-018-31707-9
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  • Zadoo S, Nguyen A, Zode G, et al. A Novel Luciferase Assay For Sensitively Monitoring Myocilin Variants in Cell Culture. Invest Ophthalmol Vis Sci. 2016,57(4):1939-50. doi: 10.1167/iovs.15-18789
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  • Chen DJ, Xu YM, Zheng W, et al. Proteomic analysis of secreted proteins by human bronchial epithelial cells in response to cadmium toxicity. Proteomics. 2015,15(17):3075-86. doi: 10.1002/pmic.201400489
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  • Boso G, Somia NV. Characterization of resistance to rhabdovirus and retrovirus infection in a human myeloid cell line. PLoS One. 2015,10(3):e0121455. doi: 10.1371/journal.pone.0121455
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