GSK046

MedChem Express

GSK046 [2474876-09-8]

9

2474876-09-8

Research Use Only

99.65

C23H27FN2O4

414.47

GSK046 (iBET-BD2) is a potent, selective and orally active BD2 bromodomain inhibitor of the BET proteins, with IC 50 s of 264 nM ( BRD2 BD2 ), 98 nM ( BRD3 BD2 ), 49 nM ( BRD4 BD2 ) and 214 nM ( BRDT BD2 ), respectively. GSK046 has immunomodulatory activity [1] .

O=C(N[C@H]1CC[C@H](O)CC1)C2=CC(O[C@H](C3=CC=CC=C3)C)=C(NC(C)=O)C(F)=C2

-20°C,2°C to 8°C

12352200