GSK046

AbMole BioScience

GSK046

9

2474876-09-8

Chemical

Research Use Only

C23H27FN2O4

414.47

GSK046 (iBET-BD2) is an effective, selective and orally active inhibitor of the BD2 bromine domain of the BET protein,IC50 The values are 264 nM (BRD2 BD2), 98 nM (BRD3 BD2), 49 nM (BRD4 BD2), and 214 nM (BRDT BD2). GSK046 has immunomodulatory activity.

CC(OC1=CC(=CC(=C1NC(C)=O)F)C(=O)NC2CCC(O)CC2)C3=CC=CC=C3

12352200