GSK3 alpha/beta Polyclonal Antibody

Reddot Biotech

GSK3 alpha/beta Polyclonal Antibody

5

Western Blot, ELISA, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Research Use Only

Polyclonal

1 mg/ml

Unconjugated

GSK3A

glycogen synthase kinase 3 alpha

glycogen synthase kinase-3 alpha; GSK-3 alpha; serine/threonine-protein kinase GSK3A

Rabbit

IgG

Glycogen synthase kinase-3 (GSK-3) was initially identified as an enzyme that regulates glycogen synthesis in response to insulin. GSK-3 is a ubiquitously expressed serine/threonine protein kinase that phosphorylates and inactivates glycogen synthase. GSK-3 is a critical downstream element of the PI3 kinase/Akt cell survival pathway whose activity can be inhibited by Akt-mediated phosphorylation at Ser21 of GSK-3Oe+/- and Ser9 of GSK-3betaGSK-3 has been implicated in the regulation of cell fate in Dictyostelium and is a component of the Wnt signaling pathway required for Drosophila, Xenopus and mammalian development. GSK-3 has been shown to regulate cyclin D1 proteolysis and subcellular localization.

Human, Mouse, Rat

-20°C

12352203