Bio-Connect

GSK3 beta antibody [C1C3]

GTX111192
GeneTex
ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
TargetGSK3B
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Overview

  • Supplier
    GeneTex
  • Product Name
    GSK3 beta antibody [C1C3]
  • Delivery Days Customer
    9
  • Application Supplier Note
    WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    ImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    1.57 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID2932
  • Target name
    GSK3B
  • Target description
    glycogen synthase kinase 3 beta
  • Target synonyms
    glycogen synthase kinase-3 beta; GSK-3 beta; serine/threonine-protein kinase GSK3B
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDP49841
  • Protein Name
    Glycogen synthase kinase-3 beta
  • Scientific Description
    Glycogen synthase kinase-3 (GSK3) is a proline-directed serine-threonine kinase that was initially identified as a phosphorylating and inactivating glycogen synthase (see GYS1, MIM 138570). Two isoforms, alpha (GSK3A; MIM 606784) and beta, show a high degree of amino acid homology (Stambolic and Woodgett, 1994 [PubMed 7980435]). GSK3B is involved in energy metabolism, neuronal cell development, and body pattern formation (Plyte et al., 1992 [PubMed 1333807]).[supplied by OMIM]
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

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  • The Long-Term DEHP Exposure Confers Multidrug Resistance of Triple-Negative Breast Cancer Cells through ABC Transporters and Intracellular ROS. Jadhao M et al., 2021 Jun 11, Antioxidants (Basel)
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  • Oral administration of bovine milk-derived extracellular vesicles induces senescence in the primary tumor but accelerates cancer metastasis. Samuel M et al., 2021 Jun 24, Nat Commun
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  • Chaperonin-Containing TCP-1 Promotes Cancer Chemoresistance and Metastasis through the AKT-GSK3beta-beta-Catenin and XIAP-Survivin Pathways. Chang YX et al., 2020 Dec 21, Cancers (Basel)
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  • Sclareol ameliorated ERCC1-mediated cisplatin resistance in A549 human lung adenocarcinoma cells and a murine xenograft tumor model by suppressing AKT-GSK3beta-AP1/Snail and JNK-AP1 pathways. Pan CH et al., 2020 Dec 1, Chem Biol Interact
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  • The Role of Wnt/beta-Catenin Pathway Mediators in Aortic Valve Stenosis. Khan K et al., 2020, Front Cell Dev Biol
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  • The three-phase enriched environment paradigm promotes neurovascular restorative and prevents learning impairment after ischemic stroke in rats. Zhan Y et al., 2020 Dec, Neurobiol Dis
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  • LncRNA TTN-AS1/miR-134-5p/PAK3 axis regulates the radiosensitivity of human large intestine cancer cells through the P21 pathway and AKT/GSK-3beta/beta-catenin pathway. Zuo Z et al., 2020 Nov, Cell Biol Int
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  • Moscatilin Ameliorates Tau Phosphorylation and Cognitive Deficits in Alzheimers Disease Models. Huang JM et al., 2019 Jul 26, J Nat Prod
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  • miR-214 targets the PTEN-mediated PI3K/Akt signaling pathway and regulates cell proliferation and apoptosis in ovarian cancer. Liu J et al., 2017 Nov, Oncol Lett
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