Western Blot analysis of Hela, Jurkat cells using GSK3 alpha/beta Polyclonal Antibody at dilution of 1:1000.
Western Blot analysis of Hela, Jurkat cells using GSK3 alpha/beta Polyclonal Antibody at dilution of 1:1000.
GSK3alpha/beta Polyclonal Antibody
E-AB-31628
Product group Antibodies
Overview
- SupplierElabscience
- Product NameGSK3alpha/beta Polyclonal Antibody
- Delivery Days Customer12
- Applications SupplierWB,IHC,ELISA
- CertificationResearch Use Only
- Concentration1 mg/ml
- Scientific DescriptionGlycogen synthase kinase-3 (GSK-3) was initially identified as an enzyme that regulates glycogen synthesis in response to insulin. GSK-3 is a ubiquitously expressed serine/threonine protein kinase that phosphorylates and inactivates glycogen synthase. GSK-3 is a critical downstream element of the PI3 kinase/Akt cell survival pathway whose activity can be inhibited by Akt-mediated phosphorylation at Ser21 of GSK-3alpha and Ser9 of GSK-3betaGSK-3 has been implicated in the regulation of cell fate in Dictyostelium and is a component of the Wnt signaling pathway required for Drosophila, Xenopus and mammalian development. GSK-3 has been shown to regulate cyclin D1 proteolysis and subcellular localization.
- UNSPSC12352203